Zhong Guo-Chen, Zhou Peng
School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China.
Department of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, Anhui, China.
Mol Cell Biochem. 2025 Jul 13. doi: 10.1007/s11010-025-05352-6.
Natural polysaccharides are a potential therapy for cardiovascular diseases (CVDs) resulting from intestinal barrier injury. More studies on the protective effects of natural polysaccharides on intestinal barrier injury are being conducted, although the underlying mechanisms remain unknown. Thus, the objective of this paper is to discuss current research on natural polysaccharides to reduce the risk of CVDs by preventing intestinal barrier injury. In addition, the protective benefits of natural polysaccharides against CVDs are explored. Finally, the preliminary structure-activity relationship of natural polysaccharides was discussed, which provided the theoretical basis for the modification of lead compound. These natural polysaccharides can enhance the intestinal barrier function of the intestine, hence preventing the incidence and development of CVDs.
天然多糖是一种针对肠道屏障损伤引发的心血管疾病（CVD）的潜在治疗方法。目前正在开展更多关于天然多糖对肠道屏障损伤保护作用的研究，尽管其潜在机制尚不清楚。因此，本文的目的是讨论目前关于天然多糖通过预防肠道屏障损伤来降低心血管疾病风险的研究。此外，还探讨了天然多糖对心血管疾病的保护作用。最后，讨论了天然多糖初步的构效关系，为先导化合物的修饰提供了理论依据。这些天然多糖可以增强肠道的肠道屏障功能，从而预防心血管疾病的发生和发展。
