Stochl Jan, Clarke Nathan, Green Daniel, Comins Jonathan, Higgins Victoria, Piercy James, Arbuckle Rob, Halasa Tariq, Rocha Thaís, Khunti Kamlesh
Adelphi Values, Bollington, UK.
Department of Kinanthropology, Charles University, Prague, Czechia.
Diabetes Obes Metab. 2025 Sep;27(9):5032-5041. doi: 10.1111/dom.16551. Epub 2025 Jul 14.
To evaluate the psychometric properties of the Adelphi Adherence Questionnaire (ADAQ©) as an adherence measure in a diverse type 2 diabetes mellitus (T2DM) population in routine clinical practice.
Data were drawn from the Adelphi T2DM Disease Specific Programme™, a survey of physicians and adults with T2DM consulting in the United States, February-May 2021. Participants completed the ADAQ and single questions on medication satisfaction and convenience. Latent variable modelling (exploratory/confirmatory factor analyses, item response theory, Mokken scaling and bifactor analyses) assessed ADAQ dimensionality and composite scoring. Differential item functioning (DIF) analyses were conducted between participants taking injectable and non-injectable therapies, and with <3 or ≥3 long-term conditions. Correlational analyses with physician-reported adherence and compliance, and patient-reported treatment satisfaction, convenience and side-effects assessed construct validity. ADAQ scores by sociodemographic and clinical factors were also described.
Overall, 1287 people with T2DM were included in this analysis (mean age 56.7 years [standard deviation: 12.8], 54.5% [n = 702] male). Latent variable modelling indicated a unidimensional reflective model fit, with a bifactor model confirming an 11-question essentially unidimensional composite score. Negligible DIF was found between groups. Cronbach's alpha and McDonald's omega were both ≥0.90. Moderate correlations with physician-reported adherence and compliance, and patient-reported medication convenience and satisfaction support construct validity.
The ADAQ shows strong construct validity and high internal consistency reliability within a heterogenous T2DM population with negligible DIF between sub-groups. Future work should focus on test-retest reliability and detecting change over time.
评估阿德尔菲依从性问卷（ADAQ©）作为常规临床实践中不同2型糖尿病（T2DM）人群依从性测量工具的心理测量特性。
数据来自阿德尔菲T2DM疾病特定项目™，这是一项于2021年2月至5月在美国对医生和患有T2DM的成年人进行的调查。参与者完成了ADAQ以及关于药物满意度和便利性的单项问题。潜在变量建模（探索性/验证性因素分析、项目反应理论、莫肯量表分析和双因素分析）评估了ADAQ的维度和综合评分。对接受注射和非注射治疗的参与者以及患有<3种或≥3种长期疾病的参与者进行了差异项目功能（DIF）分析。通过与医生报告的依从性和顺从性以及患者报告的治疗满意度、便利性和副作用进行相关性分析来评估结构效度。还描述了按社会人口统计学和临床因素划分的ADAQ分数。
总体而言，本分析纳入了1287名T2DM患者（平均年龄56.7岁[标准差：12.8]，54.5%[n = 702]为男性）。潜在变量建模表明单维反射模型拟合良好，双因素模型确认了一个由11个问题组成的基本单维综合评分。各亚组之间的DIF可忽略不计。克朗巴赫α系数和麦克唐纳ω系数均≥0.90。与医生报告的依从性和顺从性以及患者报告的药物便利性和满意度的中度相关性支持了结构效度。
ADAQ在异质性T2DM人群中显示出强大的结构效度和高内部一致性可靠性，亚组之间的DIF可忽略不计。未来的工作应侧重于重测信度以及检测随时间的变化。
Zotero 插件