Wilkinson Ashley R, Conner Bobbi J, Serpa Priscila B S
Virginia-Maryland College of Veterinary Medicine, Blacksburg, Virginia, USA.
Vet Clin Pathol. 2025 Jul 14. doi: 10.1111/vcp.70027.
Thromboelastography (TEG) provides a global assessment of hemostasis and identifies patients with both hemorrhagic and thrombotic tendencies. Traditional TEG instruments, such as the TEG 5000 (Haemonetics), can be labor-intensive and require specialized training to operate. The TEG 6s (Haemonetics) is a commercially available point-of-care TEG that employs a cartridge-based system. Agreement between the TEG 6s and TEG 5000 is poor in dogs, and their viscoelastic measurements are not interchangeable. Reference intervals specific to the TEG 6s are needed for healthy adult dogs.
This study aimed to establish reference intervals for the TEG 6s in healthy adult dogs.
Citrated whole blood samples collected from 40 healthy adult dogs were analyzed using the TEG 6s and associated global hemostasis and lysis cartridges. Reference intervals were established using a nonparametric statistical method for all variables except for the Functional Fibrinogen level in the global hemostasis cartridge.
Reference intervals were established for 12 TEG 6s measurands in healthy adult dogs.
The results of this study provide reference intervals for TEG 6s variables associated with the global hemostasis and lysis cartridges in healthy adult dogs. Further studies are required to assess TEG 6s' utility in dogs with various disease states.
血栓弹力图（TEG）可对止血进行全面评估，并识别有出血和血栓形成倾向的患者。传统的TEG仪器，如TEG 5000（Haemonetics公司），操作起来可能需要耗费大量人力，且需要专门培训。TEG 6s（Haemonetics公司）是一种商用的即时检测TEG，采用基于试剂盒的系统。在犬类中，TEG 6s与TEG 5000之间的一致性较差，它们的粘弹性测量结果不可互换。健康成年犬需要特定于TEG 6s的参考区间。
本研究旨在建立健康成年犬TEG 6s的参考区间。
使用TEG 6s以及相关的全面止血和溶解试剂盒，对从40只健康成年犬采集的枸橼酸盐全血样本进行分析。除全面止血试剂盒中的功能性纤维蛋白原水平外，对所有变量均采用非参数统计方法建立参考区间。
建立了健康成年犬12项TEG 6s测量指标的参考区间。
本研究结果提供了与健康成年犬全面止血和溶解试剂盒相关的TEG 6s变量的参考区间。需要进一步研究以评估TEG 6s在患有各种疾病状态的犬类中的效用。
