Unlocking the therapeutic potential of RNA splicing in lung fibrosis: Insights from the SRSF7-PKM axis.
作者信息
Ding Bi-Sen
机构信息
Key Lab of Birth Defects and Related Diseases of Women and Children of MOE, State Key Lab of Biotherapy, State Key Laboratory of Respiratory Health and Multimorbidity, West China Second University Hospital, College of Life Sciences, Sichuan University, Chengdu 610064, China.
出版信息
Acta Pharm Sin B. 2025 Jun;15(6):3351-3352. doi: 10.1016/j.apsb.2025.05.028. Epub 2025 Jun 24.
Abstract
摘要
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本文引用的文献
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RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition.RUNX2通过肺泡向病理性成纤维细胞转变促进纤维化。
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Science. 2024 Dec 13;386(6727):eado5561. doi: 10.1126/science.ado5561.
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Lomitapide for the treatment of homozygous familial hypercholesterolaemia in children.洛美他派用于治疗儿童纯合子家族性高胆固醇血症。
Lancet Diabetes Endocrinol. 2024 Dec;12(12):866-867. doi: 10.1016/S2213-8587(24)00277-8. Epub 2024 Oct 16.
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Inhibiting endothelial blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration.抑制内皮细胞阻断致纤维化的血管内套叠和血管生成因子，以维持肺再生。
Sci Transl Med. 2024 Aug 28;16(762):eado5266. doi: 10.1126/scitranslmed.ado5266.
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Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis.内皮细胞 TPI1 的多巴胺化抑制铁死亡性血管分泌信号，促进肺再生而不是纤维化。
Cell Metab. 2024 Aug 6;36(8):1839-1857.e12. doi: 10.1016/j.cmet.2024.07.008.
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Lung regeneration: diverse cell types and the therapeutic potential.肺再生：多种细胞类型及其治疗潜力。
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