Ndemuweda Tulonga, Kitaura Hideki, Ohori Fumitoshi, Marahleh Aseel, Ma Jinghan, Fan Ziqiu, Lin Angyi, Narita Kohei, Itou Arata, Mizoguchi Itaru
Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, Sendai, Japan.
Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, Sendai, Japan.
J Dent Sci. 2025 Jul;20(3):1415-1421. doi: 10.1016/j.jds.2025.02.017. Epub 2025 Feb 25.
BACKGROUND/PURPOSE: Orthodontic treatment is one of the most demanding procedures available for both patients and clinicians. The challenges stem from the extended duration to achieve desired results, often necessitating surgical interventions, such as micro-osteoperforations (MOPs). This study aimed to investigate the biological effects and extent of changes resulting from these interventions. Specifically, we evaluated the degree of root resorption during orthodontic tooth movement accelerated by MOPs.
We assessed the tooth movement rates and root resorption in eight-to ten-week-old male mice. A nickel-titanium (Ni-Ti) closed-coil spring was applied between the maxillary left first molar and maxillary incisors. In the MOPs group, micro-perforations were made on the mesial and palatal surfaces of the left maxillary first molar. Odontoclast formation and root resorption were assessed using histological analysis and scanning electron microscopy.
Tooth movement was greater in the MOPs group. Odontoclast formation was remarkably higher in this group than in the orthodontic tooth movement (OTM) group. Additionally, more extensive root resorption was observed on the mesial surface of the distobuccal root of the left maxillary first molar.
Root resorption significantly increased in mice with MOPs. These findings highlight the need to carefully consider the risk of root resorption in patients undergoing MOPs during orthodontic treatment.
背景/目的：正畸治疗对患者和临床医生来说都是要求极高的治疗手段之一。挑战源于实现预期效果所需的较长时间，这通常需要手术干预，如微骨穿孔术（MOPs）。本研究旨在调查这些干预措施产生的生物学效应和变化程度。具体而言，我们评估了微骨穿孔术加速正畸牙齿移动过程中的牙根吸收程度。
我们评估了8至10周龄雄性小鼠的牙齿移动速率和牙根吸收情况。在上颌左侧第一磨牙和上颌切牙之间施加镍钛（Ni-Ti）闭合螺旋弹簧。在微骨穿孔术组中，在上颌左侧第一磨牙的近中和腭侧表面进行微穿孔。使用组织学分析和扫描电子显微镜评估破牙细胞的形成和牙根吸收情况。
微骨穿孔术组的牙齿移动更大。该组破牙细胞的形成明显高于正畸牙齿移动（OTM）组。此外，在上颌左侧第一磨牙远中颊根的近中表面观察到更广泛的牙根吸收。
微骨穿孔术小鼠的牙根吸收显著增加。这些发现凸显了在正畸治疗中接受微骨穿孔术的患者需要仔细考虑牙根吸收风险的必要性。
