Shen Wen-Ying, Lai Wei-Ju, Wang Yu-Hsun, Chang Yu-Chao
Executive Master Program in Health Policy and Management, College of Health Care and Management, Chung Shan Medical University, Taichung, Taiwan.
Hinew Dental Clinic, Changhua, Taiwan.
J Dent Sci. 2025 Jul;20(3):1749-1755. doi: 10.1016/j.jds.2025.04.002. Epub 2025 Apr 15.
BACKGROUND/PURPOSE: Lung cancer is the most common cause of cancer death globally. However, the association between chronic periodontitis (CP) and lung cancer risk is still not very clear. The aim of study was to investigate whether the Taiwanese female patients with CP might have increased risk of lung cancer using a nationwide registry dataset in Taiwan.
A retrospective cohort study was conducted by using Taiwanese Longitudinal Health Insurance Database. A total of 86,886 patients who were newly diagnosed with CP from 2001 to 2012 were selected. A 1:1 propensity-matched healthy patients without any type of periodontal diseases were captured randomly from the general population. The risk of lung cancer was analyzed by Cox proportional hazards regression models between CP and non-CP cohorts.
639 and 614 patients with newly diagnosed lung cancer were found in CP and non-CP cohorts, respectively. CP cohort exhibited a borderline significantly increased risk of lung cancer (relative risk:1.01 95 % CI: 0.90-1.12) as compared with non-CP cohort. The subgroup analysis of hazard ratio for sex difference, for interaction was 0.042. The female patients with CP had a 1.23-fold higher risk of lung cancer than non-CP counterparts (95 % CI: 1.01-1.48, = 0.036).
Taken together, the results of this nationwide population-based cohort study indicate that the Taiwanese female patients with CP exhibited a significantly higher risk of lung cancer than those female patients without CP.
背景/目的：肺癌是全球癌症死亡的最常见原因。然而，慢性牙周炎（CP）与肺癌风险之间的关联仍不太明确。本研究的目的是利用台湾的全国性登记数据集，调查台湾患有CP的女性患者患肺癌的风险是否会增加。
使用台湾纵向健康保险数据库进行一项回顾性队列研究。共选取了2001年至2012年新诊断为CP的86,886例患者。从普通人群中随机抽取1:1倾向匹配的无任何类型牙周疾病的健康患者。通过Cox比例风险回归模型分析CP组和非CP组之间肺癌的风险。
CP组和非CP组分别有639例和614例新诊断为肺癌的患者。与非CP组相比，CP组肺癌风险有临界显著增加（相对风险：1.01，95%可信区间：0.90 - 1.12）。性别差异风险比的亚组分析，交互作用为0.042。患有CP的女性患者患肺癌的风险比非CP女性患者高1.23倍（95%可信区间：1.01 - 1.48，P = 0.036）。
总体而言，这项基于全国人群的队列研究结果表明，台湾患有CP的女性患者患肺癌的风险明显高于未患CP的女性患者。
