Wodeyar Anirudh, Chinappen Dhinakaran, Kwon Hunki, Shi Wen, Richardson Mark, Kramer Mark A, Chu Catherine J
Department of Advanced Computing Sciences, Maastricht University, Maastricht, The Netherlands.
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
bioRxiv. 2025 May 8:2025.05.06.652436. doi: 10.1101/2025.05.06.652436.
The cross-regional interplay of slow oscillations, sleep spindles, and ripples during sleep is believed to support systems memory consolidation but is understudied in humans. Using a validated behavioral task and intracranial neural recordings from orbitofrontal cortex, thalamus, and hippocampus in 19 epilepsy patients, we examined the cross-regional interplay of sleep-oscillations and their role in memory consolidation. Orbitofrontal slow oscillations robustly modulate sleep rhythms both within and across regions. Most combinations of oscillation rates predict overnight memory consolidation, but hippocampal ripple rate and coupled hippocampal-orbitofrontal ripples were the strongest positive predictors of memory consolidation. In contrast, epileptic spikes coupled to sleep oscillations strongly predicted reduced memory consolidation, with the strongest negative effect observed when epileptic spikes were coupled to slow oscillations. These findings provide direct evidence of the hierarchical cascade of sleep oscillations in human memory processing and reveal how epileptic spikes disrupt this process in patients with epilepsy.
睡眠期间慢波振荡、睡眠纺锤波和涟漪的跨区域相互作用被认为有助于系统记忆巩固，但在人类中对此研究较少。我们使用经过验证的行为任务以及对19名癫痫患者眶额皮质、丘脑和海马体进行的颅内神经记录，研究了睡眠振荡的跨区域相互作用及其在记忆巩固中的作用。眶额慢波振荡有力地调节区域内和区域间的睡眠节律。大多数振荡频率组合可预测夜间记忆巩固情况，但海马体涟漪频率以及海马体与眶额皮质耦合的涟漪是记忆巩固最强的正向预测指标。相比之下，与睡眠振荡耦合的癫痫棘波强烈预示着记忆巩固能力下降，当癫痫棘波与慢波振荡耦合时，观察到的负面影响最为强烈。这些发现为人类记忆处理中睡眠振荡的层级级联提供了直接证据，并揭示了癫痫棘波如何在癫痫患者中破坏这一过程。
