Swanson Rachel A, Chinigò Elisa, Levenstein Daniel, Vöröslakos Mihály, Mousavi Navid, Wang Xiao-Jing, Basu Jayeeta, Buzsáki György
Neuroscience Institute, Langone Medical Center, New York University, New York, NY, USA.
Center for Neural Science, New York University, New York, NY, USA.
Neuron. 2025 Mar 5;113(5):754-768.e9. doi: 10.1016/j.neuron.2024.12.019. Epub 2025 Jan 27.
Systems consolidation relies on coordination between hippocampal sharp-wave ripples (SWRs) and neocortical UP/DOWN states during sleep. However, whether this coupling exists across the neocortex and the mechanisms enabling it remains unknown. By combining electrophysiology in mouse hippocampus (HPC) and retrosplenial cortex (RSC) with wide-field imaging of the dorsal neocortex, we found spatially and temporally precise bi-directional hippocampo-neocortical interaction. HPC multi-unit activity and SWR probability were correlated with UP/DOWN states in the default mode network (DMN), with the highest modulation by the RSC in deep sleep. Further, some SWRs were preceded by the high rebound excitation accompanying DMN DOWN → UP transitions, whereas large-amplitude SWRs were often followed by DOWN states originating in the RSC. We explain these electrophysiological results with a model in which the HPC and RSC are weakly coupled excitable systems capable of bi-directional perturbation and suggest that the RSC may act as a gateway through which SWRs can perturb downstream cortical regions via cortico-cortical propagation of DOWN states.
系统巩固依赖于睡眠期间海马体尖波涟漪（SWRs）与新皮质UP/ DOWN状态之间的协调。然而，这种耦合是否存在于整个新皮质以及实现它的机制仍然未知。通过将小鼠海马体（HPC）和压后皮质（RSC）的电生理学与背侧新皮质的宽场成像相结合，我们发现了空间和时间上精确的双向海马体 - 新皮质相互作用。HPC多单位活动和SWR概率与默认模式网络（DMN）中的UP/ DOWN状态相关，在深度睡眠中RSC的调制作用最强。此外，一些SWRs之前伴随着DMN从DOWN到UP转变的高反弹兴奋，而大振幅SWRs之后往往是起源于RSC的DOWN状态。我们用一个模型来解释这些电生理结果，其中HPC和RSC是能够双向扰动的弱耦合可兴奋系统，并表明RSC可能充当一个通道，通过它SWRs可以通过DOWN状态的皮质 - 皮质传播来扰动下游皮质区域。
