Dissegna L, Ambrosio G B, Zamboni S, Santonastaso P, Canton G, Mioni E, Prattichizzo F, Dal Palù C
G Ital Cardiol. 1985 Jun;15(6):571-5.
The possibility that antihypertensive drug treatment may induce neurotic symptoms was investigated in a random sample of 114 hypertensives enrolled in an "Hypertension Register" by means of the Kellner and Sheffield Symptom Rating Test (S.R.T.). Of them 73 were on antihypertensive treatment; 41 untreated subjects constituted the control group. Covariance analysis adjusting for age and diastolic blood pressure was used as a statistical test. The comparison between treated and not treated hypertensive subjects did not show any significant difference either for total S.R.T. score (12.6 vs 10.6 in M, 11.6 vs 14.6 in F), or for the partial scores of anxiety (3.5 vs 3.0 in M, 3.1 vs 3.4 in F), depression (2.4 vs 2.2 in M, 2.7 vs 3.5 in F), somatization (4.2 vs 3.2 in M, 3.9 vs 5.6 in F), inadequacy (2.4 vs 2.1 in M, 1.9 vs 2.1 in F). Taking into account the total group (M + F) of treated hypertensives, no significant differences were observed between different treatments (reserpine, alphamethyldopa, clonidine; beta-blockers, diuretics). However beta-blockers and clonidine showed the highest scores for total S.R.T. score (17.3 and 13.2 respectively). The study suggests that the antihypertensive drugs taken into consideration, at least at the given regime, do not induce such psychological side effects as to prevent them being used in a programme of secondary prevention of hypertension.
通过凯尔纳和谢菲尔德症状评定测试（S.R.T.），对纳入“高血压登记册”的114名高血压患者的随机样本进行了研究，以探讨抗高血压药物治疗可能诱发神经症状的可能性。其中73人正在接受抗高血压治疗；41名未治疗的受试者组成对照组。采用对年龄和舒张压进行校正的协方差分析作为统计检验。接受治疗和未接受治疗的高血压受试者之间的比较显示，无论是S.R.T.总分（男性为12.6对10.6，女性为11.6对14.6），还是焦虑、抑郁、躯体化、不足等部分得分（男性焦虑为3.5对3.0，女性为3.1对3.4；男性抑郁为2.4对2.2，女性为2.7对3.5；男性躯体化为4.2对3.2，女性为3.9对5.6；男性不足为2.4对2.1，女性为1.9对2.1）均无显著差异。考虑到接受治疗的高血压患者的总体（男性+女性），不同治疗方法（利血平、甲基多巴、可乐定；β受体阻滞剂、利尿剂）之间未观察到显著差异。然而，β受体阻滞剂和可乐定的S.R.T.总分最高（分别为17.3和13.2）。该研究表明，至少在所给定的治疗方案下，所考虑的抗高血压药物不会诱发足以妨碍其用于高血压二级预防方案的此类心理副作用。
