Nah Gabriel D, Hohmann Andrea G, Port Nicholas, Crystal Jonathon D
Indiana University, Bloomington.
bioRxiv. 2025 May 1:2025.04.28.650881. doi: 10.1101/2025.04.28.650881.
Mild Traumatic Brain Injury (mTBI), or concussion, is the most common form of traumatic brain injury, which accounts for about 80% of cases. It is a common problem in contact sports and may lead to cognitive impairment. This study used the Wayne State University closed-head weight-drop model in lightly anesthetized and unrestrained Long Evans rats. This model allows for the rapid acceleration and deceleration of the head and torso, similar to the biomechanics in human mTBI. Rats were administered a single weight drop. Sham animals were treated the same as the mTBI group but were not subjected to weight drop. Rats were trained in an 8-arm radial maze to assess spatial working memory before and after weight drop manipulation. We observed that the injured rats' spatial working memory performance significantly declined compared to the sham rats (cohen's d = 1.88). Specifically, the performance of the sham group continued to improve after the sham procedure, whereas the performance of the injury group decreased. This study suggests the WDM model produces a deficit in spatial working memory in rats.
轻度创伤性脑损伤（mTBI），即脑震荡，是创伤性脑损伤最常见的形式，约占病例的80%。它在接触性运动中是一个常见问题，可能导致认知障碍。本研究在轻度麻醉且未受束缚的Long Evans大鼠中使用了韦恩州立大学闭合性颅脑重物坠落模型。该模型能够实现头部和躯干的快速加速和减速，类似于人类mTBI中的生物力学情况。给大鼠进行单次重物坠落。假手术动物的处理方式与mTBI组相同，但不进行重物坠落。在重物坠落操作前后，对大鼠进行八臂放射状迷宫训练以评估空间工作记忆。我们观察到，与假手术大鼠相比，受伤大鼠的空间工作记忆表现显著下降（科恩d值 = 1.88）。具体而言，假手术组在假手术操作后表现持续改善，而损伤组的表现则下降。本研究表明，重物坠落模型会导致大鼠空间工作记忆缺陷。
