Hoet J J
MMW Munch Med Wochenschr. 1977 May 13;119(19):659-62.
The metabolic and hormonal adaptation of the maternal organism in pregnancy, the glucose dependency of the fetus, the adaptation of the fetus to the pregnancy and the clinical consequences of the adaptation are important aspects of pregnancy in diabetics. Hyperglycemia in the mother possibly leads to a fetal anoxia by reducing the oxygen in the maternal hemoglobin and at the same time to a hyperglycemia of the fetus which causes hyperinsulinism. The consequences of hyperinsulinism are, inter alia, adiposity and respiratory insufficiency in the child due to hyaline membranes. Insulin treatment of the mother before and during pregnancy in order to normalize the blood sugar level is consequently absolutely essential to prevent such complications.
孕期母体的代谢和激素适应、胎儿对葡萄糖的依赖、胎儿对妊娠的适应以及这种适应的临床后果是糖尿病患者妊娠的重要方面。母亲的高血糖可能通过降低母体血红蛋白中的氧气含量导致胎儿缺氧,同时导致胎儿高血糖,进而引起高胰岛素血症。高胰岛素血症的后果包括,尤其是由于透明膜导致儿童肥胖和呼吸功能不全。因此,在怀孕前和怀孕期间对母亲进行胰岛素治疗以使血糖水平正常化对于预防此类并发症绝对至关重要。