爱泼斯坦-巴尔病毒诱导的微小病变病：传染性单核细胞增多症中肾病综合征的一个病因

Epstein-Barr Virus-Induced Minimal Change Disease: A Cause of Nephrotic Syndrome in Infectious Mononucleosis.

作者信息

Ghatak Srijeet, Bose Prapa

机构信息

Gastroenterology, Ealing Hospital, Croydon, GBR.

Internal Medicine, Epsom and St Helier Hospital, Sutton, GBR.

出版信息

Cureus. 2025 Jul 5;17(7):e87315. doi: 10.7759/cureus.87315. eCollection 2025 Jul.

DOI:10.7759/cureus.87315

PMID:40655059

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12255827/

Abstract

Infectious mononucleosis (IM), caused by the Epstein-Barr virus (EBV), typically presents as a self-limiting illness characterized by fever, pharyngitis, and lymphadenopathy. While subclinical renal involvement is not uncommon, acute kidney injury (AKI) and nephrotic syndrome due to EBV are rare. We present the case of an 18-year-old woman with EBV-induced IM complicated by minimal change disease (MCD), resulting in nephrotic syndrome. The patient responded promptly to steroid therapy, highlighting the importance of considering EBV in the differential diagnosis of minimal change nephropathy.

摘要

传染性单核细胞增多症（IM）由爱泼斯坦-巴尔病毒（EBV）引起，通常表现为一种自限性疾病，其特征为发热、咽炎和淋巴结病。虽然亚临床肾受累并不少见，但EBV引起的急性肾损伤（AKI）和肾病综合征却很罕见。我们报告一例18岁女性，患有EBV诱发的IM并并发微小病变病（MCD），导致肾病综合征。该患者对类固醇治疗反应迅速，这突出了在微小病变肾病的鉴别诊断中考虑EBV的重要性。