Dhebar Mruga Malay, Reddy A Likhitha, Natarajan Kishore Kumar, Seelan Ap Aravinda Sathya, Manikandan R, Ganesan Aswin, Shingala Harsh Chandulal, Rameshbabu Sushmitha, Prashanth A
Department of Cardiology, Wythenshawe Hospital, MFT, Wythenshawe, Manchester, United Kingdom.
Department of General Medicine, Madras Medical College, EVR Periyar Salai, Near G H Hospital, Park Town, Chennai, Tamil Nadu, India.
J Pharm Bioallied Sci. 2025 Jun;17(Suppl 2):S1194-S1196. doi: 10.4103/jpbs.jpbs_1586_24. Epub 2025 Jun 18.
Acute pancreatitis (AP) is a sudden inflammatory process of the pancreas that can lead to varying degrees of severity, ranging from mild discomfort to life-threatening conditions. Identifying key inflammatory markers at an early stage is crucial to predicting clinical outcomes and improving management.
This study aims to evaluate the association between inflammatory markers-C-reactive protein (CRP), serum amylase, and white blood cell (WBC) count-and clinical outcomes in patients with acute pancreatitis.
A prospective cohort study involving 120 patients diagnosed with AP was conducted. Inflammatory markers were measured at admission, and their relationship with clinical outcomes, including hospital stay, severity of pancreatitis, and complications, was assessed.
Elevated CRP and WBC count were associated with severe pancreatitis and poor outcomes. Serum amylase showed no significant correlation with the severity of the disease. CRP was the strongest predictor of prolonged hospital stay and complications.
CRP is a reliable inflammatory marker for predicting severe clinical outcomes in AP, suggesting its use for routine monitoring in clinical practice.
急性胰腺炎（AP）是胰腺的一种突发炎症过程，可导致不同程度的严重程度，从轻度不适到危及生命的状况。在早期识别关键炎症标志物对于预测临床结果和改善治疗至关重要。
本研究旨在评估炎症标志物——C反应蛋白（CRP）、血清淀粉酶和白细胞（WBC）计数——与急性胰腺炎患者临床结果之间的关联。
进行了一项前瞻性队列研究，纳入120例诊断为AP的患者。在入院时测量炎症标志物，并评估它们与临床结果的关系，包括住院时间、胰腺炎严重程度和并发症。
CRP和WBC计数升高与重症胰腺炎和不良结果相关。血清淀粉酶与疾病严重程度无显著相关性。CRP是住院时间延长和并发症的最强预测指标。
CRP是预测AP严重临床结果的可靠炎症标志物，表明其可用于临床实践中的常规监测。
