Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria.

BACKGROUND

Peri-implantitis, a prevalent complication of dental implants, is characterized by inflammation and bone loss caused by bacterial colonization around the implant surface. Nano-hydroxyapatite (nHA)-coated implants have shown promise in enhancing osseointegration and providing antibacterial properties.

MATERIALS AND METHODS

A total of 40 dental implants were divided into two groups: Group A ( = 20) comprised nHA-coated implants, and Group B ( = 20) comprised uncoated titanium implants (control). The implants were incubated with , , and for 7 days. Antibacterial efficacy was assessed by quantifying colony-forming units (CFUs) using culture techniques. Additionally, biofilm formation on implant surfaces was evaluated using scanning electron microscopy (SEM).

RESULTS

Group A demonstrated a significant reduction in bacterial adhesion and biofilm formation compared to Group B ( < .05). The mean CFU counts for , , and in Group A were 1.2 × 10, 0.9 × 10, and 0.8 × 10, respectively, compared to 3.5 × 10, 2.8 × 10, and 2.4 × 10 in Group B. SEM analysis revealed a thinner biofilm layer on nHA-coated implants, indicating superior antibacterial activity.

CONCLUSION

Nano-hydroxyapatite-coated implants significantly inhibit the growth of peri-implantitis-associated bacteria and reduce biofilm formation, making them a promising alternative for reducing peri-implantitis risk. Further clinical studies are warranted to validate these findings.