Ketter Nicole I, Rash Isabelle, Yang Michelle C, Park Sarah, Sakakibara Brodie M
Graduate Program in Rehabilitation Sciences, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Centre for Chronic Disease Prevention and Management, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada.
J Multimorb Comorb. 2025 Jul 10;15:26335565251356668. doi: 10.1177/26335565251356668. eCollection 2025 Jan-Dec.
Cardiometabolic multimorbidity (CM), two or more of stroke, diabetes, and heart disease is increasing in prevalence and associated with a multiplicative mortality risk. Sex differences exist in disability outcomes for those with stroke, diabetes, and heart disease, and thus are likely for those with CM.
To assess 1) sex differences in the prevalence of CM, 2) sex differences in disability variables amongst those with CM, and 3) the predicted probabilities of disability among people with and without CM by sex.
A secondary analysis using data from the Canadian Longitudinal Study on Aging (CLSA). The CLSA included a stratified, random sample of approximately 51,000 participants aged 45 to 85 at recruitment. Independent variables include depressive symptoms, pain, high blood pressure, eyesight, limitations with activities of daily living (ADL), and social participation.
A weighted population of 13,204,82 participants were included, 659,621 had CM. Males had a higher prevalence of CM than females, accounting for 62% of those with CM. Females with CM had a higher probability than males of reporting high depressive symptoms (females: 29% [95%CI:27%-31%], males: 21% [95%CI:19%-23%]), pain (females: 49% [95%CI:47%-52%], males: 41% [95%CI:39%-43%]), and limitations with ADL (females: 27% [95%CI:25%-29%], males: 11% [95%CI:10%-13%]) Males with CM had a higher probability than females of reporting infrequent social participation (females: 18% [95%CI:16%-20%], males: 23% [95%CI:21%-25%]).
This study provides evidence on sex differences in the likelihood of reporting disability variables in individuals with CM. These insights into sex differences can inform targeted interventions and improve patient outcomes.
心脏代谢性多种疾病（CM），即中风、糖尿病和心脏病中的两种或更多种疾病，其患病率正在上升，且与成倍增加的死亡风险相关。中风、糖尿病和心脏病患者的残疾结局存在性别差异，因此CM患者可能也存在性别差异。
评估1）CM患病率的性别差异，2）CM患者中残疾变量的性别差异，以及3）有和没有CM的人群按性别划分的残疾预测概率。
使用来自加拿大老龄化纵向研究（CLSA）的数据进行二次分析。CLSA包括一个分层随机样本，招募时年龄在45至85岁之间的约51,000名参与者。自变量包括抑郁症状、疼痛、高血压、视力、日常生活活动（ADL）受限和社会参与情况。
纳入了加权后的13,204,82名参与者，其中659,621人患有CM。男性CM患病率高于女性，占CM患者的62%。患有CM的女性比男性更有可能报告高抑郁症状（女性：29%[95%CI：27%-31%]，男性：21%[95%CI：19%-23%]）、疼痛（女性：49%[95%CI：47%-52%]，男性：41%[95%CI：39%-43%]）以及ADL受限（女性：27%[95%CI：25%-29%]，男性：11%[95%CI：10%-13%]）。患有CM的男性比女性更有可能报告社会参与不频繁（女性：18%[95%CI：16%-20%]，男性：23%[95%CI：21%-25%]）。
本研究提供了关于CM患者报告残疾变量可能性的性别差异的证据。这些关于性别差异的见解可为有针对性的干预措施提供参考，并改善患者结局。
