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小儿葡萄球菌烫伤样皮肤综合征合并耐甲氧西林金黄色葡萄球菌感染及类固醇滥用:一例报告

Pediatric Staphylococcal Scalded Skin Syndrome Complicated by Methicillin-Resistant Staphylococcus Aureus and Steroid Abuse: A Case Report.

作者信息

Jha Ujjwal Kumar, Yadav Ajay Kumar

机构信息

Grande International Hospital, Dhapasi, Kathmandu, Nepal.

Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2024 Oct;62(278):697-699. doi: 10.31729/jnma.8770. Epub 2024 Oct 31.

Abstract

Staphylococcal Scalded Skin Syndrome (SSSS) is a severe exfoliative skin condition primarily affecting children, caused by the toxins produced by This case report describes the clinical presentation, diagnostic challenges, and successful management of SSSS complicated by Methicillin-Resistant (MRSA) in a pediatric patient. A pediatric patient presented with a two-week history of pruritic vesiculobullous eruptions that progressively worsened. Despite initial treatments with various topical and oral medications including steroid and antibiotic ointments, the lesions continued to progress. A wound culture identified heavy growth of MRSA, prompting a change in the treatment regimen, resulting in significant clinical improvement. This case underscores the importance of accurate diagnosis and timely intervention in the management of SSSS, particularly when complicated by MRSA. The successful outcome with appropriate antibiotic therapy highlights the need for a multidisciplinary approach and emphasizes the value of culture and sensitivity testing in guiding effective treatment strategies.

摘要

葡萄球菌烫伤样皮肤综合征(SSSS)是一种主要影响儿童的严重剥脱性皮肤病,由金黄色葡萄球菌产生的毒素引起。本病例报告描述了一名儿科患者中合并耐甲氧西林金黄色葡萄球菌(MRSA)的SSSS的临床表现、诊断挑战及成功治疗。一名儿科患者有两周的瘙痒性水疱大疱性皮疹病史,且病情逐渐加重。尽管最初使用了包括类固醇和抗生素软膏在内的各种局部和口服药物进行治疗,但皮损仍继续进展。伤口培养发现大量MRSA生长,促使改变治疗方案,从而使临床症状显著改善。该病例强调了在SSSS治疗中准确诊断和及时干预的重要性,尤其是在合并MRSA时。适当抗生素治疗取得的成功结果凸显了多学科方法的必要性,并强调了培养和药敏试验在指导有效治疗策略方面的价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b16/11619542/0e584efed090/JNMA-62-278-697-g1.jpg

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