Völker Maja P, Sirignano Lea, Dukal Helene, Schwesinger Alexander, Findeisen Peter, Schummer Fabian, Hummel Nils, Bresele Juliana, Schneider Michael, Behr Joachim, Stamm Thomas, Zolk Oliver, Pietzner Anne, Hauptmann Michael, Graßhof Tino, Hartlep Michael, Decker Manfred, Müller Anne, Gerlach Frank, Vonau Winfried, Witt Stephanie H, Granger Douglas A, Parkin Georgia M, Thomas Elizabeth A, Gilles Maria, Buspavanich Pichit
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Department of Psychiatry and Psychotherapy, RG Stress, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.
Neurosci Appl. 2024 Apr 13;3:104067. doi: 10.1016/j.nsa.2024.104067. eCollection 2024.
Lithium is one of the most effective medications for treatment-resistant depression and bipolar disorder. However, lithium has a narrow therapeutic window: overdosing can lead to life-threatening lithium intoxication while underdosing results in a lack of desired therapeutic effects. Therefore, lithium treatment requires close monitoring with regular laboratory assessments of blood serum concentrations. An alternative method for monitoring lithium at home would increase the safety and empowerment of patients. In our project, we are investigating the potential of saliva as a readily accessible medium. We are exploring a) the best method for collecting and processing saliva, b) methods to measure salivary lithium levels, and c) the correlation between blood serum and saliva concentrations of lithium, and influencing factors; with the aim to develop a Point-of-care home testing device.
锂是治疗难治性抑郁症和双相情感障碍最有效的药物之一。然而，锂的治疗窗很窄：过量服用会导致危及生命的锂中毒，而剂量不足则会导致缺乏预期的治疗效果。因此，锂治疗需要通过定期实验室评估血清浓度进行密切监测。在家中监测锂的另一种方法将提高患者的安全性和自主性。在我们的项目中，我们正在研究唾液作为一种易于获取的介质的潜力。我们正在探索：a）收集和处理唾液的最佳方法；b）测量唾液锂水平的方法；c）血清和唾液中锂浓度之间的相关性以及影响因素；旨在开发一种即时护理家庭检测设备。
