Solis-Pazmino Daniel, Baldin Roberta, Guarçoni Magno, Bertinatto Ricardo, Maldonado Pedro, Cedeno Andres, Ma Rachel, Coral Roberto Pelegrini, Solis-Pazmino Paola
Department of Oral and Maxillofacial Surgery, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Avenida Ipiranga, 6681 Partenón, Porto Alegre, RS 90619-900, Brazil.
CaTaLiNA- Cancer de Tiroides en Latino América, Quito, Ecuador.
J Surg Case Rep. 2025 Jul 12;2025(7):rjaf417. doi: 10.1093/jscr/rjaf417. eCollection 2025 Jul.
Oropharyngeal squamous cell carcinoma (OPSCC) commonly metastasizes to the lungs, bones, and distant lymph nodes. Liver metastases from OPSCC are rare and typically occur in advanced stages. We present a 59-year-old male diagnosed with OPSCC, initially treated with surgery followed by adjuvant radiotherapy (RDT). Due to political and governmental limitations, the patient received only six sessions of RDT, below the standard recommended regimen. Three years post-treatment, he presented with abdominal symptoms, and imaging revealed a hepatic lesion. A liver biopsy confirmed metastatic squamous cell carcinoma. Histopathological comparison with the primary tumor supported the diagnosis of hepatic metastasis from OPSCC. This case underscores the aggressive nature of OPSCC and the critical importance of completing multimodal therapy. Interrupted adjuvant treatment may have contributed to early distant spread. While liver metastases from OPSCC are rare, they should be considered in patients presenting with compatible symptoms and a history of incomplete treatment.
口咽鳞状细胞癌（OPSCC）通常会转移至肺部、骨骼和远处淋巴结。OPSCC的肝转移很少见，且通常发生在晚期。我们报告一例59岁男性，被诊断为OPSCC，最初接受手术治疗，随后进行辅助放疗（RDT）。由于政治和政府方面的限制，该患者仅接受了六次RDT，低于标准推荐方案。治疗三年后，他出现腹部症状，影像学检查发现肝脏有病变。肝脏活检证实为转移性鳞状细胞癌。与原发肿瘤的组织病理学比较支持OPSCC肝转移的诊断。该病例强调了OPSCC的侵袭性以及完成多模式治疗的至关重要性。辅助治疗中断可能导致了早期远处转移。虽然OPSCC的肝转移很少见，但对于出现相关症状且有治疗不完整病史的患者应予以考虑。
