Mohamed Tarek, Elhashamy Hamza, Ramez Mohamed, Bickers Adam, Phull Jaspal
Urology, United Lincolnshire Hospitals NHS Trust, Lincoln, GBR.
Urology, Assiut University Hospitals, Assuit, EGY.
Cureus. 2025 Jun 11;17(6):e85779. doi: 10.7759/cureus.85779. eCollection 2025 Jun.
Bladder cancer is a prevalent malignancy globally, significantly affecting patient quality of life, morbidity, mortality, and healthcare costs. Disparities in bladder cancer incidence and mortality rates among countries result from varying risk factors, detection methods, and diagnostic techniques. Enhanced imaging has led to more precise staging, while advancements in surgical techniques have been paired with superior chemotherapy protocols. Bladder cancer frequently metastasises to the lymph nodes, bone, liver, lung, and peritoneum, but rarely to the breast. Metastases to the breast originating from bladder cancer present difficulties in identification and require standard invasive techniques. We report a case of a 79-year-old female diagnosed with a muscle-invasive bladder tumour who underwent a positron emission tomography-computed tomography (PET-CT) scan that demonstrated significant localised activity within the right breast. An ultrasound scan and mammography of the right breast revealed a 10 mm ill-defined mass in the upper outer quadrant and two minor ill-defined masses measuring 6mm and 10mm in the upper inner quadrant, with no concomitant axillary lymphadenopathy. A core cut biopsy and immunohistochemistry of the prior lesions were performed, which are morphologically and immunophenotypically similar, supporting a diagnosis of metastatic urothelial carcinoma.
膀胱癌是全球一种常见的恶性肿瘤，严重影响患者的生活质量、发病率、死亡率及医疗成本。各国膀胱癌发病率和死亡率的差异源于不同的风险因素、检测方法和诊断技术。增强成像技术已使分期更为精确，同时手术技术的进步与更优的化疗方案相辅相成。膀胱癌常转移至淋巴结、骨、肝、肺和腹膜，但很少转移至乳腺。源自膀胱癌的乳腺转移瘤在识别上存在困难，需要采用标准的侵入性技术。我们报告一例79岁女性，诊断为肌层浸润性膀胱肿瘤，接受了正电子发射断层扫描-计算机断层扫描（PET-CT）检查，结果显示右乳内有明显的局限性活性。右乳超声扫描和乳腺X线摄影显示，外上象限有一个10毫米边界不清的肿块，内上象限有两个较小的边界不清的肿块，大小分别为6毫米和10毫米，无腋窝淋巴结肿大。对先前病变进行了芯针活检和免疫组织化学检查，其形态学和免疫表型相似，支持转移性尿路上皮癌的诊断。
