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卡培他滨诱发的白质脑病：一例报告

Capecitabine-Induced Leukoencephalopathy: A Case Report.

作者信息

Waheed Midhat, Yasmeen Ammara, Malik Farzan, Fatima Tanveer, Bano Sheher, Tarar Zubia, Siddiqi Harris, Ul Ain Noor

机构信息

Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, PAK.

Medical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Centre, lahore, PAK.

出版信息

Cureus. 2025 Jun 11;17(6):e85756. doi: 10.7759/cureus.85756. eCollection 2025 Jun.

DOI:10.7759/cureus.85756
PMID:40656323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12247148/
Abstract

Capecitabine, an antineoplastic agent, is an orally active fluorinated pyrimidine that is metabolized to the active form, fluorouracil (FU), by the enzyme thymidine phosphorylase. Neurologic complications secondary to capecitabine are uncommon, especially leukoencephalopathy, which develops shortly after starting treatment, is quite rare. This report details a young man who developed this complication after receiving just the first cycle, and discontinuation of the causative agent led to clinical and radiological improvement.

摘要

卡培他滨是一种抗肿瘤药物，是一种口服活性氟代嘧啶，通过胸苷磷酸化酶代谢为活性形式氟尿嘧啶（FU）。卡培他滨继发的神经并发症并不常见，尤其是在开始治疗后不久发生的白质脑病，极为罕见。本报告详细介绍了一名年轻男子，他仅在接受第一个疗程后就出现了这种并发症，停用致病药物后临床和影像学表现均有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e16/12247148/7002f039d933/cureus-0017-00000085756-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e16/12247148/488822209f50/cureus-0017-00000085756-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e16/12247148/7002f039d933/cureus-0017-00000085756-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e16/12247148/488822209f50/cureus-0017-00000085756-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e16/12247148/7002f039d933/cureus-0017-00000085756-i02.jpg

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本文引用的文献

1
Capecitabine related neurotoxicity: Clinical and radiologic features.卡培他滨相关性神经毒性：临床和影像学特征。
J Neurol Sci. 2022 Nov 15;442:120444. doi: 10.1016/j.jns.2022.120444. Epub 2022 Sep 30.
2
Oxaliplatin-induced posterior reversible encephalopathy syndrome (PRES).奥沙利铂诱发的后部可逆性脑病综合征（PRES）。
BMJ Case Rep. 2017 Oct 4;2017:bcr-2017-221571. doi: 10.1136/bcr-2017-221571.
3
Capecitabine-induced acute toxic leukoencephalopathy.卡培他滨引起的急性毒性脑白质病。
Neurotoxicology. 2017 Sep;62:1-5. doi: 10.1016/j.neuro.2017.05.001. Epub 2017 May 6.
4
Capecitabine-induced leukoencephalopathy involving the bilateral corticospinal tracts.卡培他滨诱导的白质脑病累及双侧皮质脊髓束。
J Radiol Case Rep. 2016 Mar 31;10(3):1-10. doi: 10.3941/jrcr.v10i3.2686. eCollection 2016 Mar.
5
Capecitabine-induced multifocal leukoencephalopathy: a report of five cases.卡培他滨诱发的多灶性白质脑病：5例报告
Neurology. 2005 Dec 13;65(11):1792-4; discussion 1685. doi: 10.1212/01.wnl.0000187313.83515.7e. Epub 2005 Oct 19.