Manoharan Mmahaletchumy, Shahid Muhammad Hamza, Abbasi Daniyal, Pooja Lohana, Hasan Abdul Haseeb
General Surgery, University of North Sumatra, Medan, IDN.
Internal Medicine, Akhtar Saeed Medical and Dental College, Lahore, PAK.
Cureus. 2025 Jun 13;17(6):e85933. doi: 10.7759/cureus.85933. eCollection 2025 Jun.
We report a rare and aggressive presentation of hepatocellular carcinoma in a 50-year-old man with a brief history of hepatitis B infection. The patient presented with a rapidly enlarging epigastric mass, recurrent hematemesis, and a newly developed left-sided varicocele. Imaging revealed a large exophytic hepatic mass with evidence of vascular displacement and intrahepatic metastases. Histopathological examination confirmed a diagnosis of poorly differentiated hepatocellular carcinoma. A multidisciplinary tumor board recommended palliative surgical debulking followed by systemic therapy to address tumor burden and improve quality of life. This case highlights the diagnostic and management challenges associated with atypical presentations of hepatocellular carcinoma in patients with minimal liver disease history.
我们报告了一例罕见且侵袭性强的肝细胞癌病例,患者为一名50岁男性,有短暂的乙型肝炎感染史。患者表现为上腹部肿块迅速增大、反复呕血以及新出现的左侧精索静脉曲张。影像学检查显示肝脏有一个巨大的外生性肿块,有血管移位和肝内转移的迹象。组织病理学检查确诊为低分化肝细胞癌。一个多学科肿瘤委员会建议进行姑息性手术减瘤,然后进行全身治疗以减轻肿瘤负担并改善生活质量。该病例凸显了在肝病病史极少的患者中,肝细胞癌非典型表现所带来的诊断和管理挑战。