Sequeira Quesada Carlos, Vega Monge Maria Alexandra
Neurology, Universidad de Costa Rica, San José, CRI.
Neurology, Caja Costarricense del Seguro Social (CCSS), San José, CRI.
Cureus. 2025 Jun 12;17(6):e85856. doi: 10.7759/cureus.85856. eCollection 2025 Jun.
Classic definitions describe optic neuritis as an acute, unilateral loss of vision accompanied by an afferent pupillary defect and eye pain, with normal ophthalmoscopy in most cases. Advancements in paraclinical tests have dichotomized clinical presentations into typical and atypical optic neuritis, with the latter requiring additional testing to establish a diagnosis of definite or probable optic neuritis. Compromise of the second cranial nerve in optic neuritis expands beyond inflammation and demyelination and includes systemic and infectious entities, more commonly catalyzing atypical clinical presentations. We present the case of a male patient with atypical optic neuritis, based on its clinical course and imaging findings, who was ultimately diagnosed with extranodal marginal zone B-cell lymphoma (EMZL), a type of non-Hodgkin MALT lymphoma. The effect of the optic nerve in this pathology has only been sparsely reported.
经典定义将视神经炎描述为急性单侧视力丧失，伴有传入性瞳孔障碍和眼痛，大多数情况下眼底检查正常。临床检查的进展将临床表现分为典型和非典型视神经炎，后者需要额外检查以确诊或疑似视神经炎。视神经炎中第二对脑神经的损害不仅包括炎症和脱髓鞘，还包括全身性和感染性疾病，更常见地引发非典型临床表现。我们报告一例非典型视神经炎男性患者，根据其临床病程和影像学表现，最终诊断为结外边缘区B细胞淋巴瘤（EMZL），一种非霍奇金黏膜相关淋巴组织淋巴瘤。这种病理情况下视神经的影响仅有少量报道。
