Nguyen Justin, Liang Yao, Islam Abir, Kakarala Venu, Overturf Matthew D
Medicine, Edward Via College of Osteopathic Medicine, Monroe, USA.
Outpatient Internal Medicine, Zachary Internal Medicine, Slaughter, USA.
Cureus. 2025 Jun 13;17(6):e85940. doi: 10.7759/cureus.85940. eCollection 2025 Jun.
Gout is a metabolic disorder characterized by acute and chronic inflammatory responses due to monosodium urate (MSU) crystal deposition, commonly affecting the first metatarsophalangeal joint, hands, and/or knees. While this condition is typically self-limiting, recurrent cases can suggest an underlying contributor. Low-dose aspirin is commonly used as a cardiovascular prophylaxis. Although research is limited, aspirin has been implicated in decreased uric acid excretion, thus potentially exacerbating gout symptoms in patients. This case highlights a 67-year-old African American male who presented to a clinic complaining of gout in his right hand. Despite following strict lifestyle practices and medication compliance, pharmacological therapies were rendered ineffective until aspirin was identified as a contributing factor to his gout. Optimizing his medication regimen resolved his gout attacks, which stresses the concept that clinicians must be diligent with lesser-known side effects of medication to improve patient outcomes.
痛风是一种代谢紊乱疾病，其特征是由于尿酸钠（MSU）晶体沉积引起急性和慢性炎症反应，通常影响第一跖趾关节、手部和/或膝盖。虽然这种情况通常是自限性的，但复发病例可能提示存在潜在的促成因素。低剂量阿司匹林通常用于心血管疾病的预防。尽管相关研究有限，但阿司匹林与尿酸排泄减少有关，因此可能会加重患者的痛风症状。本病例重点介绍了一名67岁的非裔美国男性，他到诊所就诊，主诉右手痛风。尽管他严格遵循生活方式并遵医嘱服药，但药物治疗一直无效，直到发现阿司匹林是导致他痛风的一个因素。优化他的药物治疗方案后，他的痛风发作得到缓解，这强调了临床医生必须留意药物鲜为人知的副作用以改善患者治疗效果的理念。
