Mibielli Marco Antonio N, Suchmacher Mendel, Geller Mauro, Mezitis Spyros G E, Nunes Carlos P, Sintoveter Aline
Centro Universitário Serra dos Órgãos, Teresópolis, RJ, Brazil.
Postgraduate Program in Immunology, Instituto de Pós-graduação Médica Carlos Chagas, Rio de Janeiro, RJ, Brazil.
Rev Bras Ortop (Sao Paulo). 2025 Jul 10;60(2):1-9. doi: 10.1055/s-0045-1804495. eCollection 2025 Apr.
Low back pain is a common complaint. This syndrome comprehends different underlying mechanisms, which are difficult to differentiate in a timely manner only through semiotic, laboratory, and imaging resources available in an emergency setting. Such circumstances make practitioners prone to an initial symptomatic approach in the form of medications (non-steroid anti-inflammatory drugs, analgesics, muscle relaxants) or local procedures (local heat, massage). Peripheral neurotrophic substances, such as pyrimidine nucleotides (uridine triphosphate and cytidine monophosphate) combined with vitamin B12 (hydroxocobalamin), have been used as anabolic precursors able to provide spinal nerve roots with triggering elements useful for nerve and glial cells regeneration, once a likely spinal compression mechanism is contained. The authors performed a systematic review and meta-analysis with the above combination with the aim of better determining its role in low back pain management.
下背痛是一种常见的病症。该综合征包含不同的潜在机制，仅通过急诊环境中可用的症状学、实验室和影像学资源很难及时区分这些机制。这种情况使得从业者倾向于采用药物（非甾体抗炎药、镇痛药、肌肉松弛剂）或局部治疗（局部热敷、按摩）等初始对症治疗方法。一旦可能的脊髓压迫机制得到控制，外周神经营养物质，如嘧啶核苷酸（三磷酸尿苷和一磷酸胞苷）与维生素B12（羟钴胺）联合使用，已被用作合成代谢前体，能够为脊神经根提供对神经和神经胶质细胞再生有用的触发元素。作者对上述组合进行了系统评价和荟萃分析，目的是更好地确定其在下背痛管理中的作用。
