Tiwari Archana, Sapkota Pratima
Department of Pathology, Lumbini Medical College, Tansen, Palpa, Nepal.
JNMA J Nepal Med Assoc. 2025 Feb;63(282):88-92. doi: 10.31729/jnma.8883. Epub 2025 Feb 28.
Uterine leiomyoma, also known as a fibroid, is a benign mesenchymal tumor derived from the smooth muscle of the uterus. It is the most common tumor in women with an estimated incidence of 20%-40% in women during their reproductive years. Leiomyoma can occur in any organ, but the most common forms appear in the uterus. This study is conducted to analyze histomorphological patterns of uterine leiomyomas.
An observational cross-section was conducted between 1st June 2021 and 31st May 2023 in the Department of Pathology of a Medical College and Teaching Hospital. Patients with leiomyoma were included in the study. Clinical, sonographic, gross, and histopathology findings were analyzed. Ethical approval for the study was obtained from Institutional Review Committee (Reference Number: LMC10/B-021).
There were 100 patients with leiomyoma during the study period, among whom 55 (55%) were 40-49 years old. There were 65 (65%) patients in the group with a parity of two to three. Abnormal uterine bleeding was observed in 60 (60%) of the cases. Histologically 84 (84%) of the cases were simple conventional leiomyoma. The co-existing conditions found were cystic ovarian disease 37 (41.11%), adenomyosis 19 (21.11%), cervical intra epithelial neoplasia 12(13.33%).
Conventional leiomyoma is the commonest histological subtype and and the most common clinical presentation is abnormal uterine bleeding.
子宫平滑肌瘤，也称为纤维瘤，是一种源自子宫平滑肌的良性间叶组织肿瘤。它是女性中最常见的肿瘤，估计在育龄期女性中的发病率为20%-40%。平滑肌瘤可发生于任何器官，但最常见的形式出现在子宫。本研究旨在分析子宫平滑肌瘤的组织形态学模式。
于2021年6月1日至2023年5月31日在一所医学院及教学医院的病理科进行了一项观察性横断面研究。纳入患有平滑肌瘤的患者。对临床、超声、大体及组织病理学检查结果进行分析。本研究获得了机构审查委员会的伦理批准（参考编号：LMC10/B-021）。
研究期间有100例平滑肌瘤患者，其中55例（55%）年龄在40-49岁。产次为2至3次的患者有65例（65%）。60例（60%）病例观察到子宫异常出血。组织学上，84例（84%）病例为单纯性传统平滑肌瘤。发现的并存疾病有囊性卵巢疾病37例（41.11%）、子宫腺肌病19例（21.11%）、宫颈上皮内瘤变12例（13.33%）。
传统平滑肌瘤是最常见的组织学亚型，最常见的临床表现是子宫异常出血。
