卓-艾综合征中西咪替丁耐药性的发展。
Development of cimetidine resistance in the Zollinger-Ellison syndrome.
作者信息
Andersen B N, Larsen N E, Rune S J, Worning H
出版信息
Gut. 1985 Nov;26(11):1263-5. doi: 10.1136/gut.26.11.1263.
Abstract
A patient with the Zollinger-Ellison syndrome was followed with multiple gastric secretion tests and serum gastrin analyses for six years. During this period cimetidine requirement increased to a daily dose of 8 g, but it reversed spontaneously after two years. The altered cimetidine effectiveness was not associated with reduced oral bioavailability and serum calcium was unchanged. Total serum gastrin was very high at all times, and fractionation of gastrins in serum by gel filtration showed varying proportion of big to small gastrins, but not in a mode which explained the parietal cell resistance to cimetidine.
摘要
对一名患有卓-艾综合征的患者进行了为期六年的多次胃液分泌试验和血清胃泌素分析。在此期间，西咪替丁的需求量增加到每日8克，但两年后又自行逆转。西咪替丁疗效的改变与口服生物利用度降低无关，血清钙也未发生变化。血清总胃泌素一直非常高，通过凝胶过滤对血清中的胃泌素进行分离显示，大胃泌素与小胃泌素的比例各不相同，但并非以能解释壁细胞对西咪替丁产生抵抗的模式变化。
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本文引用的文献
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Clin Chim Acta. 1983 Jan 7;127(1):29-39. doi: 10.1016/0009-8981(83)90072-4.
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Similar acid stimulatory potencies of synthetic human big and little gastrins in man.合成的人胃泌素-17和胃泌素-34对人体胃酸分泌的刺激作用相似。
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Failure of cimetidine in Zollinger-Ellison syndrome.西咪替丁治疗卓-艾综合征失败。
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