Quatrini M, Basilisco G, Conte D, Bardella M T, Bozzani A, Bianchi P A
Am J Gastroenterol. 1984 May;79(5):345-7.
A secretin provocative test was performed in 16 patients with chronic duodenal ulcer and in five patients with the Zollinger-Ellison syndrome. In four chronic duodenal ulcer patients a second secretin test was done during acute iv cimetidine administration. There were only slight variations of gastrin compared with the first test. A third test was done on the same four chronic duodenal ulcer patients after 1 month's po cimetidine treatment (1 g/day); gastrin at 0 time was significantly higher than in the previous two tests (p less than 0.01). Integrated gastrin response after secretin was significantly lower in the third test than in the first (p less than 0.05). In two Zollinger-Ellison syndrome patients treated with 1.0 and 1.4 g/day cimetidine for 3 months, gastrin at 0 time was not markedly increased, whereas compared with the first test gastrin levels were higher at each time after secretin. These data suggest that previous cimetidine treatment does not alter, and may even increase, the diagnostic sensitivity of the secretin test.
对16例慢性十二指肠溃疡患者和5例佐林格-埃利森综合征患者进行了促胰液素激发试验。在4例慢性十二指肠溃疡患者急性静脉注射西咪替丁期间进行了第二次促胰液素试验。与第一次试验相比，胃泌素仅有轻微变化。在4例慢性十二指肠溃疡患者接受为期1个月的口服西咪替丁治疗（1克/天）后进行了第三次试验；0时的胃泌素水平显著高于前两次试验（p<0.01）。第三次试验中促胰液素后的胃泌素综合反应显著低于第一次试验（p<0.05）。在2例接受1.0克/天和1.4克/天西咪替丁治疗3个月的佐林格-埃利森综合征患者中，0时的胃泌素没有明显升高，而与第一次试验相比，促胰液素后各时间点的胃泌素水平更高。这些数据表明，先前的西咪替丁治疗不会改变，甚至可能提高促胰液素试验的诊断敏感性。
