Li Jiqing, Lu Yuexin, Li Jiapeng, Wang Jian, Liu Zhengzheng, Meshkov Oleg, Yang Jinfeng, Fan Kuanjun
State Key Laboratory of Advanced Electromagnetic Technology, Huazhong University of Science and Technology, Wuhan, China.
Budker Institute of Nuclear Physics SB RAS, Novosibirsk, Russia.
Front Oncol. 2025 Jun 27;15:1508361. doi: 10.3389/fonc.2025.1508361. eCollection 2025.
To ensure the safety and efficacy of precise proton therapy, real-time and non-intrusive monitoring of the clinical beam position is essential. However, in cyclotron-based proton therapy facilities, clinical proton beams with low repetition frequency and exceptionally low intensity due to the Energy Selection Systems (ESS), pose considerable challenges for accurate online beam diagnostics. Conventional non-interceptive beam diagnostic devices lack the sensitivity required to detect such weak beams with sufficient precision.
This paper presents an innovative solution to this challenge: an off-centerrectangular cavity Beam Position Monitor (BPM) with dielectric loading. This novel design achieves remarkable position sensitivity while maintaining compact transverse dimensions of 500×250×100 mm.
A prototype of this cavity has been fabricated and tested offline. Experimental results demonstrate that, within the clinical treatment energy range, the BPM achieves minimum beam position measurement sensitivities of 0.49 nV/mm at 70 MeV and 17.12 nV/mm at 230 MeV. In addition to enabling online beam position monitoring without disturbing the beam path, which ensures real-time beam orbit feedback correction with submillimeter stability (± 0.5 mm).
In addition to monitoring beam positions for precise control of the beam orbit, the BPMs could serve additional functions to enhance proton therapy-such as enabling beam energy verification through the phase of the BPM signal.
为确保精确质子治疗的安全性和有效性,对临床束流位置进行实时且非侵入式监测至关重要。然而,在基于回旋加速器的质子治疗设施中,由于能量选择系统(ESS),临床质子束的重复频率低且强度极低,这给精确的在线束流诊断带来了巨大挑战。传统的非拦截式束流诊断设备缺乏足够的灵敏度来精确检测如此微弱的束流。
本文提出了一种应对这一挑战的创新解决方案:一种带有介质加载的偏心矩形腔束流位置监测器(BPM)。这种新颖的设计在保持500×250×100毫米紧凑横向尺寸的同时,实现了显著的位置灵敏度。
该腔体的一个原型已制造出来并进行了离线测试。实验结果表明,在临床治疗能量范围内,该BPM在70兆电子伏特时实现了最低束流位置测量灵敏度为0.49纳伏/毫米,在230兆电子伏特时为17.12纳伏/毫米。除了能够在不干扰束流路径的情况下进行在线束流位置监测外,这还确保了具有亚毫米稳定性(±0.5毫米)的实时束流轨道反馈校正。
除了监测束流位置以精确控制束流轨道外,BPM还可以发挥其他功能来增强质子治疗——例如通过BPM信号的相位实现束流能量验证。