赞比亚患者胃十二指肠疾病与空腹胃液褪黑素水平的关系：一项横断面研究。

Fasting Gastric Juice Melatonin Levels in Relation to Gastroduodenal Pathologies Among Zambian Patients: A Cross Sectional Study.

作者信息

Sibande Jonathan, Hankolwe Mutinta Nyama, Kelly Paul, Kayamba Violet

机构信息

University of Zambia School of Medicine Lusaka Zambia.

Tropical Gastroenterology and Nutrition Group Lusaka Zambia.

出版信息

Health Sci Rep. 2025 Jul 10;8(7):e71053. doi: 10.1002/hsr2.71053. eCollection 2025 Jul.

DOI:10.1002/hsr2.71053

PMID:40657300

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12245987/

Abstract

BACKGROUND AND AIMS

Melatonin is a hormone released from the pineal gland and enterochromaffin cells of the gastrointestinal tract. The influence of melatonin on gastric pathologies is not fully investigated. Our aim was to evaluate the relationship between fasting gastric juice melatonin levels and gastroduodenal pathologies among Zambian patients.

METHODS

This cross-sectional study was conducted in Lusaka, Zambia. We collected morning fasting gastric juice samples from patients presenting for oesophagogastroduodenoscopy (OGD) to quantify levels of melatonin using commercial ELISA kits. Interviewer administered questionnaires were used to collect baseline characteristics. Data were analyzed in Stata version 15.

RESULTS

We collected gastric juice from 175 patients with a median age of 49 years, IQR (40-65). The number of females was 95 (54%) and males 80 (46%). Of these, 100 (57%) had normal OGD examinations, 49 (28%) peptic ulcers, 25 (14%) gastric cancer and 1 (1%) gastric polyp. The median level of melatonin in normal patients was 141.8 pg/mL, IQR (46.2-500.1). In those with gastroduodenal pathologies, the median was 339.4 pg/mL, IQR (101.8-500.1) and the difference was statistically significant, = 0.02. Results also revealed significantly higher levels of melatonin among patients with history of cigarette smoking, = 0.003.

CONCLUSION

There is an association between gastroduodenal pathology and morning gastric juice melatonin levels, a finding whose biological significance warrants further research.

摘要

背景与目的

褪黑素是一种由松果体和胃肠道肠嗜铬细胞释放的激素。褪黑素对胃部疾病的影响尚未得到充分研究。我们的目的是评估赞比亚患者空腹胃液褪黑素水平与胃十二指肠疾病之间的关系。

方法

这项横断面研究在赞比亚卢萨卡进行。我们从接受食管胃十二指肠镜检查（OGD）的患者中收集了早晨空腹胃液样本，使用商业酶联免疫吸附测定（ELISA）试剂盒来定量褪黑素水平。通过访谈者发放问卷来收集基线特征。数据在Stata 15版本中进行分析。

结果

我们收集了175名患者的胃液，这些患者的中位年龄为49岁，四分位间距（IQR）为40 - 65岁。女性有95名（54%），男性80名（46%）。其中，100名（57%）患者的OGD检查结果正常，49名（28%）患有消化性溃疡，25名（14%）患有胃癌，1名（1%）患有胃息肉。正常患者的褪黑素中位水平为141.8 pg/mL，IQR为46.2 - 500.1。在患有胃十二指肠疾病的患者中，中位水平为339.4 pg/mL，IQR为101.8 - 500.1，差异具有统计学意义，P = 0.02。结果还显示，有吸烟史的患者褪黑素水平显著更高，P = 0.003。