老年人锌摄入量及超氧化物歧化酶活性与认知功能的相关性
The Correlation Between Zinc Intake and Superoxide Dismutase Activity with Cognitive Function in the Elderly.
作者信息
Khuzaimah Rima, Witjaksono Fiastuti, Hardiany Novi Silvia
机构信息
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Department of Biochemistry & Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
出版信息
Sultan Qaboos Univ Med J. 2025 May 2;25(1):506-514. doi: 10.18295/2075-0528.2866. eCollection 2025.
OBJECTIVES
This study aimed to analyse the correlation between zinc intake and superoxide dismutase (SOD) with cognitive function in the elderly. Thus, the role of zinc as a structural component of SOD, along with SOD's contribution to cognitive function, can be established.
METHODS
This cross-sectional study was conducted at Panti Sosial Tresna Wredha Budi Mulia 1 in Jakarta, Indonesia, from July to September 2024. Elderly men and women were included. Zinc intake was assessed using the Semi-Quantitative Food Frequency Questionnaire, while plasma SOD activity was measured by spectrophotometer. Cognitive function was assessed using the Montreal Cognitive Assessment-Indonesia version. Data were analysed using bivariate testing and multivariate linear regression.
RESULTS
A total of 85 subjects were included with a median age of 69 years (61.2% were female and 38.8% male). The majority (72.9%) had primary-level education and 87.1% had chronic diseases. The mean physical activity score was 75.4 ± 39.8, the mean body mass index was 21.8 ± 3.9 kg/m and the median daily calorie intake was 1,927.8 kcal/day (range: 1,341.7-2,167.0 kcal/day). No correlation was found between zinc intake and cognitive function. However, a significant correlation ( = 0.006, = 0.296) was observed between SOD levels and cognitive function, with multivariate analysis indicating that gender, education and SOD accounted for 15.9% of the variance in cognitive function.
CONCLUSION
This study found no significant correlation between zinc intake and cognitive function. However, SOD activity were significantly correlated with cognitive function in the elderly.
目的
本研究旨在分析老年人锌摄入量和超氧化物歧化酶（SOD）与认知功能之间的相关性。从而确定锌作为SOD结构成分的作用，以及SOD对认知功能的贡献。
方法
这项横断面研究于2024年7月至9月在印度尼西亚雅加达的潘蒂社会福利机构特雷斯纳·弗雷德哈·布迪·穆利亚1进行。纳入了老年男性和女性。使用半定量食物频率问卷评估锌摄入量，同时用分光光度计测量血浆SOD活性。使用印度尼西亚版蒙特利尔认知评估量表评估认知功能。数据采用双变量检验和多元线性回归进行分析。
结果
共纳入85名受试者，中位年龄为69岁（61.2%为女性，38.8%为男性）。大多数（72.9%）接受过小学教育，87.1%患有慢性病。平均身体活动评分为75.4±39.8，平均体重指数为21.8±3.9kg/m²，每日热量摄入中位数为1927.8千卡/天（范围：1341.7 - 2167.0千卡/天）。未发现锌摄入量与认知功能之间存在相关性。然而，观察到SOD水平与认知功能之间存在显著相关性（r = 0.296，p = 0.006），多变量分析表明性别、教育程度和SOD占认知功能变异的15.9%。
结论
本研究发现锌摄入量与认知功能之间无显著相关性。然而，SOD活性与老年人的认知功能显著相关。
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