Siranart Noppachai, Nakaphan Pannathorn, Suenghataiphorn Thanathip, Fangsaard Panisara, Phanthong Tanattida, Pajareya Patavee, Phutinart Somkiat, Tirakunwichcha Pawaris, Paksin Suwit, Sowalertrat Pornnicha, Chirapongsathorn Sakkarin, Tantitanawat Kittithat
Division of Gastroenterology Hepatology and Endoscopy, Brigham and Women's Hospital Boston Massachusetts USA.
Department of Internal Medicine Weiss Memorial Hospital Chicago Illinois USA.
JGH Open. 2025 Jul 11;9(7):e70227. doi: 10.1002/jgh3.70227. eCollection 2025 Jul.
While gastrointestinal involvement is a common manifestation of systemic lupus erythematosus (SLE), the association between gastroparesis and SLE remains unclear.
We analyzed data from the National Inpatient Sample (NIS) database from 2016 to 2021. Patients with gastroparesis were categorized into SLE and non-SLE groups. Similarly, patients with SLE were categorized into gastroparesis and nongastroparesis groups. Clinical characteristics, comorbidities, hospitalization data, and outcomes were compared. The primary outcome was the association between SLE and primary gastroparesis. Secondary outcomes were clinical impacts of gastroparesis in patients with or without SLE.
A total of 12 538 228 patients were included from the NIS database. Of these, 1 165 925 patients (9.3%) were diagnosed with gastroparesis during hospitalization, while 11 372 303 patients (90.7%) did not have gastroparesis. SLE was significantly more common in patients with gastroparesis compared to those without (1.6% vs. 0.7%, < 0.001; aOR 1.87 [95% CI: 1.80-1.95]). Among patients hospitalized with gastroparesis, those with SLE had a longer length of stay, with a β-coefficient of 0.31 (95% CI: 0.07-0.55, = 0.009), lower hospitalization charges, with mean differences of $4761 (95% CI: 442-9080, = 0.031), and a higher rate of intervention needs, with odds ratios of 1.31 (95% CI: 1.09-1.56, = 0.003). After propensity-score matching (1:1), SLE patients aged ≥ 65 had higher hospital charges, with mean differences of $7287 (95% CI: 2928-11 646, = 0.01), compared to non-SLE patients.
Gastroparesis is associated with SLE, contributing to longer hospitalizations, higher costs, and increased need for invasive interventions. These findings underscore the importance of evaluating gastroparesis in SLE patients to enable early management and reduce potential complications.
虽然胃肠道受累是系统性红斑狼疮（SLE）的常见表现，但胃轻瘫与SLE之间的关联仍不明确。
我们分析了2016年至2021年国家住院样本（NIS）数据库中的数据。胃轻瘫患者被分为SLE组和非SLE组。同样，SLE患者被分为胃轻瘫组和非胃轻瘫组。比较了临床特征、合并症、住院数据和结局。主要结局是SLE与原发性胃轻瘫之间的关联。次要结局是胃轻瘫对有或无SLE患者的临床影响。
NIS数据库共纳入12538228例患者。其中，1165925例患者（9.3%）在住院期间被诊断为胃轻瘫，而11372303例患者（90.7%）没有胃轻瘫。与无胃轻瘫患者相比，胃轻瘫患者中SLE更为常见（1.6%对0.7%，P<0.001；校正后比值比1.87[95%CI：1.80-1.95]）。在因胃轻瘫住院的患者中，SLE患者住院时间更长，β系数为0.31（95%CI：0.07-0.55，P=0.009），住院费用更低，平均差异为4761美元（95%CI：442-9080，P=0.031），干预需求率更高，比值比为1.31（95%CI：1.09-1.56，P=0.003）。倾向评分匹配（1:1）后，≥65岁的SLE患者比非SLE患者住院费用更高，平均差异为7287美元（95%CI：2928-11646，P=0.01）。
胃轻瘫与SLE相关，导致住院时间延长、费用增加以及侵入性干预需求增加。这些发现强调了评估SLE患者胃轻瘫以实现早期管理并减少潜在并发症的重要性。
