Wang Yize R, Fisher Robert S, Parkman Henry P
Gastrointestinal Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Am J Gastroenterol. 2008 Feb;103(2):313-22. doi: 10.1111/j.1572-0241.2007.01658.x. Epub 2007 Nov 28.
Gastroparesis is an increasingly recognized disorder. Its prevalence in the United States is unknown. We examined the trends, characteristics, and outcomes of gastroparesis-related hospitalizations during 1995-2004.
The publicly available Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) comprises a nationally representative sample of 5-8 million hospitalizations per year. Gastroparesis-related hospitalizations were identified using the International Classification of Diseases (ICD-9) code 536.3 and compared with other hospitalizations. Multivariate regressions were used to compare for differences in the outcomes including length of stay, total charges, and in-hospital deaths.
Hospitalizations with gastroparesis as the primary diagnosis increased from 3,977 in 1995 to 10,252 in 2004 (+158%) and hospitalizations with gastroparesis as the secondary diagnosis increased from 56,726 to 134,146 (+136%). These compared to smaller changes in diabetes-related hospitalizations (+53%), all hospitalizations (+13%), and hospitalizations with gastroesophageal reflux disease (GERD), gastric ulcer, gastritis, or nonspecific nausea/vomiting as the primary diagnosis (-3% to +76%). Of the five upper gastrointestinal conditions studied as the primary diagnosis, gastroparesis had the longest length of stay (+15.4% to +66.2%, all P < 0.001) and the highest or second highest total charges (-7.2% to +60.6%, all P < 0.01) in 2004, with similar results in 1995.
The number of gastroparesis-related hospitalizations has been increasing in the United States, suggesting an increasing prevalence of gastroparesis. The economic impact of gastroparesis-related hospitalizations is significant and increasing.
胃轻瘫是一种日益受到认可的疾病。其在美国的患病率尚不清楚。我们研究了1995 - 2004年期间与胃轻瘫相关住院治疗的趋势、特征及结局。
公开可用的医疗保健成本与利用项目（HCUP）全国住院患者样本（NIS）每年包含500万至800万例具有全国代表性的住院病例。使用国际疾病分类（ICD - 9）编码536.3识别与胃轻瘫相关的住院病例，并与其他住院病例进行比较。采用多变量回归分析比较住院时间、总费用和院内死亡等结局的差异。
以胃轻瘫为主要诊断的住院病例从1995年的3977例增加到2004年的10252例（增长158%），以胃轻瘫为次要诊断的住院病例从56726例增加到134146例（增长136%）。与之相比，糖尿病相关住院病例的增长幅度较小（53%），所有住院病例增长13%，以及以胃食管反流病（GERD）、胃溃疡、胃炎或非特异性恶心/呕吐为主要诊断的住院病例增长幅度在 - 3%至76%之间。在作为主要诊断研究的五种上消化道疾病中，2004年胃轻瘫的住院时间最长（增长15.4%至66.2%，所有P < 0.001），总费用最高或第二高（增长 - 7.2%至60.6%，所有P < 0.01），1995年结果类似。
在美国，与胃轻瘫相关的住院病例数量一直在增加，表明胃轻瘫的患病率在上升。与胃轻瘫相关住院治疗的经济影响重大且在增加。
