Shah Mihir Prakash, Dahiya Dushyant Singh, Ojemolon Pius, Parikh Charmy, Shah Yash, Pinnam Bhanu Siva Mohan, Gangwani Manesh Kumar, Ali Hassam, Pan Chun-Wei, Paladiya Ruchir, Mohammed Abdul, Chandan Saurabh, Mba Benjamin, Mohan Babu P
Department of Internal Medicine University of Oklahoma Oklahoma City Oklahoma USA.
Division of Gastroenterology, Hepatology & Motility The University of Kansas School of Medicine Kansas City Kansas USA.
JGH Open. 2025 Jul 11;9(7):e70220. doi: 10.1002/jgh3.70220. eCollection 2025 Jul.
Patients diagnosed with Inflammatory bowel disease (IBD) face a notably higher risk of venous thromboembolism (VTE), leading to significant health challenges. Similarly, coronavirus disease 2019 (COVID-19) is associated with an increased susceptibility to thrombosis. We aimed to assess the impact of COVID-19 on the risk of developing VTE in patients with an underlying diagnosis of IBD.
We retrospectively analyzed the National Inpatient Sample (NIS) 2020-21 to identify adult patients with IBD admitted with or without a principal diagnosis of COVID-19. We divided these patients into three groups (without COVID-19, with uncomplicated COVID-19, and with complicated COVID-19). Hospitalization characteristics, in-hospital mortality, odds of VTE, healthcare burden, and complications were compared.
IBD patients with complicated COVID-19 infection had significantly higher odds of VTE (OR 5.60, 95% C.I. 3.63-8.65, 0.001), an increase in odds of mortality (OR 29.13, 95% C.I. 22.59-37.57, 0.001), higher healthcare resource utilization (including length of stay and total hospitalization charges), and worse secondary outcomes (like acute kidney injury and pancytopenia), compared to IBD patients without COVID-19. IBD patients with uncomplicated COVID-19 also had higher odds of VTE (OR 1.81, 95% C.I. 1.39-2.36, 0.001) than those without COVID-19; however, there was no difference in mortality or length of stay between these two groups, and those with uncomplicated COVID-19 had lower average total hospitalization charges.
Patients with both complicated and uncomplicated COVID-19 were associated with higher odds of VTE compared to those without COVID-19. Patients with complicated COVID-19, in addition, also had higher odds of mortality.
被诊断为炎症性肠病（IBD）的患者面临静脉血栓栓塞（VTE）的风险显著更高，这给健康带来了重大挑战。同样，2019冠状病毒病（COVID-19）与血栓形成易感性增加有关。我们旨在评估COVID-19对潜在诊断为IBD的患者发生VTE风险的影响。
我们回顾性分析了2020 - 21年国家住院患者样本（NIS），以确定因COVID-19有或无主要诊断而入院的成年IBD患者。我们将这些患者分为三组（无COVID-19、无并发症的COVID-19、有并发症的COVID-19）。比较了住院特征、院内死亡率、VTE几率、医疗负担和并发症。
与无COVID-19的IBD患者相比，有并发症的COVID-19感染的IBD患者发生VTE的几率显著更高（比值比5.60，95%置信区间3.63 - 8.65，P < 0.001），死亡几率增加（比值比[OR]29.13，95%置信区间22.59 - 37.57，P < 0.001），医疗资源利用率更高（包括住院时间和总住院费用），次要结局更差（如急性肾损伤和全血细胞减少）。无并发症的COVID-19的IBD患者发生VTE的几率也高于无COVID-19的患者（比值比1.81，95%置信区间1.39 - 2.36，P < 0.001）；然而，这两组之间的死亡率或住院时间没有差异，无并发症的COVID-19患者的平均总住院费用较低。
与无COVID-19的患者相比，有并发症和无并发症的COVID-19患者发生VTE的几率更高。此外，有并发症的COVID-19患者的死亡几率也更高。
