Pathangey Girish, Abdelnabi Mahmoud H, Ibrahim Ramzi, Narayanasamy Hemalatha, Sorajja Dan
Department of Cardiovascular Disease, Mayo Clinic Arizona, 5777 E. Mayo Blvd, USA, Phoenix, AZ 85054.
Eur Heart J Case Rep. 2025 Jun 25;9(7):ytaf299. doi: 10.1093/ehjcr/ytaf299. eCollection 2025 Jul.
Inadvertent temporary transvenous pacing (TTVP) of left ventricle (LV) is rare and likely underreported, posing significant embolic risk. We present a case of TTVP with atypical trajectory identified on computed tomography (CT) imaging.
A 62-year-old male with metastatic renal cell carcinoma on chemotherapy and bifascicular block presented with symptomatic bradycardia and non-ST-elevation myocardial infarction (NSTEMI), raising concerns for complete heart block on ECG. Intermittent asystole occurred during TTVP placement with appropriate capture. Post-procedure, ECG showed ventricular-paced rhythm with pseudo-right bundle branch block, and chest X-ray suggested lead placement in right ventricle; however, suboptimal echocardiography limited lead visualization. Coronary angiography revealed non-obstructive coronary artery disease. Positron emission tomography-computed tomography (PET-CT), performed to evaluate immune checkpoint inhibitor myocarditis, incidentally noted TTVP wire entering right subclavian artery and traversing to LV. Patient underwent TTVP removal, endovascular repair, and pacemaker implantation; however, course was unfortunately complicated by embolic stroke and haemorrhagic conversion.
Early detection and management of lead malposition remain critical to minimizing complications. Management strategies for inadvertent lead malposition (ILM) depend on duration of implantation, clinical presentation, and associated risks. This case highlights importance of recognizing this high-risk complication, preventive strategies, and evidence-based management. While existing data primarily focus on ILM in permanent devices, further research is needed to elucidate incidence, predictors, and outcomes of ILM in TTVP, particularly in resource-limited settings.
左心室意外临时经静脉起搏(TTVP)较为罕见,可能报道不足,存在重大栓塞风险。我们报告一例经计算机断层扫描(CT)成像发现非典型轨迹的TTVP病例。
一名62岁男性,患有转移性肾细胞癌,正在接受化疗,并有双分支阻滞,出现症状性心动过缓和非ST段抬高型心肌梗死(NSTEMI),心电图提示可能存在完全性心脏传导阻滞。在进行TTVP放置时出现间歇性心脏停搏,但捕获良好。术后心电图显示心室起搏心律伴假性右束支传导阻滞,胸部X线提示导线置于右心室;然而,超声心动图显示欠佳,限制了导线的可视化。冠状动脉造影显示冠状动脉疾病无阻塞。为评估免疫检查点抑制剂相关性心肌炎而进行的正电子发射断层扫描-计算机断层扫描(PET-CT)偶然发现TTVP导线进入右锁骨下动脉并穿至左心室。患者接受了TTVP导线移除、血管内修复和起搏器植入;然而,不幸的是,病程因栓塞性中风和出血性转化而复杂化。
早期发现和处理导线位置异常对于将并发症降至最低仍然至关重要。意外导线位置异常(ILM)的管理策略取决于植入时间、临床表现和相关风险。本病例强调了认识到这种高风险并发症、预防策略和循证管理的重要性。虽然现有数据主要关注永久性装置中的ILM,但需要进一步研究以阐明TTVP中ILM的发生率、预测因素和结局,特别是在资源有限的环境中。