Murray F T, Cameron D F, Orth J M, Katovich M J
Horm Metab Res. 1985 Oct;17(10):495-501. doi: 10.1055/s-2007-1013588.
Serum testosterone, luteinizing hormone (LH), testicular histology and ultrastructure were examined in 91 spontaneously diabetic BB, semi-starved, and control Wistar rats. Between 80-120 days of age serum testosterone was decreased (1.67 +/- .25 vs. 2.95 +/- .48 ng/ml; P less than .05) in the BB rats compared to controls but not different from semi-starved rats. LH values were similar in control and BB rats (49.4 +/- 10.9 vs. 46.8 +/- 6.2 ng/ml). Abnormal lipid droplets were noted within Leydig cells at this period. From 121-150 days of age serum testosterone was lower in BB (1.38 +/- .23 vs. 3.42 +/- .45 vs. 2.94 +/- .81 ng/ml; P less than .05) than controls or semi-starved rats. Serum LH was not significantly higher in controls than in BB rats (63.2 +/- 7.4 vs. 36.6 +/- 12 ng/ml; P = NS). Between 151-200 days of age, there was further lipid accumulation in Leydig cells in the BB rat and occasional epithelial disorganization. After 200 days, serum testosterone decreased (P less than .05) to similar levels in both control and BB rats (1.42 +/- .87 vs. 1.22 +/- .25; P = NS) and was similar in BB rats after 250 days (1.02 +/- .2 ng/ml). After 250 days of age Leydig cell morphology appeared relatively normal but marked alterations were apparent in Sertoli cells, germ cells and morphology of the tubule wall.(ABSTRACT TRUNCATED AT 250 WORDS)
对91只自发糖尿病BB大鼠、半饥饿大鼠和对照Wistar大鼠进行了血清睾酮、黄体生成素（LH）、睾丸组织学和超微结构检查。80 - 120日龄时，与对照组相比，BB大鼠血清睾酮降低（1.67±0.25 vs. 2.95±0.48 ng/ml；P＜0.05），但与半饥饿大鼠无差异。对照组和BB大鼠的LH值相似（49.4±10.9 vs. 46.8±6.2 ng/ml）。此期间，在睾丸间质细胞内发现异常脂滴。121 - 150日龄时，BB大鼠血清睾酮低于对照组或半饥饿大鼠（1.38±0.23 vs. 3.42±0.45 vs. 2.94±0.81 ng/ml；P＜0.05）。对照组血清LH不比BB大鼠显著高（63.2±7.4 vs. 36.6±12 ng/ml；P = 无显著性差异）。151 - 200日龄时，BB大鼠睾丸间质细胞有进一步的脂质蓄积，偶尔出现上皮组织紊乱。200日后，对照组和BB大鼠血清睾酮均下降（P＜0.05）至相似水平（1.42±0.87 vs. 1.22±0.25；P = 无显著性差异），250日后BB大鼠血清睾酮也相似（1.02±0.2 ng/ml）。250日龄后，睾丸间质细胞形态相对正常，但支持细胞、生殖细胞和小管壁形态出现明显改变。（摘要截短于250词）
