Murray F T, Cameron D F, Orth J M
Metabolism. 1983 Jul;32(7 Suppl 1):141-7. doi: 10.1016/s0026-0495(83)80028-6.
Diabetes which occurs spontaneously in the BB Wistar rat is associated with reduced fertility, predominantly in breeding males. In the first month of diabetes, there is a significant (p less than 0.05) reduction in serum testosterone associated with a transient decrease of serum LH and the accumulation of lipid in Leydig cells. Between one and three months of diabetes, there is an increase in both serum testosterone and LH and a further deposition of lipid droplets in Leydig cells. From three to six months of diabetes, there is a reduction of serum testosterone similar to age-matched controls, but high serum LH levels persist. Similar levels of LH and testosterone are noted after six months of diabetes, and all BB rats show marked changes in seminiferous tubules. These morphological changes in tubules consist of increased tubular wall thickness, severe germ-cell depletion, and Sertoli-cell vacuolization. Similar morphological changes of testes associated with generalized atrophy are noted in all control rats after 16 months of age. Decreased fertility in the BB rat appears to be associated with a primary disorder of Leydig cells, which precedes changes in seminiferous tubules consistent with accelerated aging. Preliminary data in impotent diabetic men suggest that the BB rat may be a valuable model for investigating human diabetic impotence and infertility.
BB 系 Wistar 大鼠自发产生的糖尿病与生育力降低有关，主要是繁殖期雄性大鼠。在糖尿病的第一个月，血清睾酮显著降低（p < 0.05），同时血清促黄体生成素短暂下降，睾丸间质细胞中脂质蓄积。糖尿病 1 至 3 个月时，血清睾酮和促黄体生成素均升高，睾丸间质细胞中脂质小滴进一步沉积。糖尿病 3 至 6 个月时，血清睾酮水平降低至与年龄匹配的对照组相似，但血清促黄体生成素水平仍维持在高位。糖尿病 6 个月后，促黄体生成素和睾酮水平相似，所有 BB 大鼠的生精小管均出现明显变化。这些小管的形态学变化包括管壁增厚、严重的生殖细胞耗竭和支持细胞空泡化。16 月龄后的所有对照大鼠睾丸均出现与普遍萎缩相关的类似形态学变化。BB 大鼠生育力降低似乎与睾丸间质细胞的原发性疾病有关，该疾病先于生精小管中与加速衰老一致的变化出现。对患有阳痿的糖尿病男性的初步数据表明，BB 大鼠可能是研究人类糖尿病性阳痿和不育症的有价值模型。
