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Am J Gastroenterol. 2025 Jan 1;120(1):106-114. doi: 10.14309/ajg.0000000000003092. Epub 2024 Sep 23.
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Initiation of vedolizumab did not provoke new-onset spondylarthritis in patients with inflammatory bowel disease: A prospective 24-week study with imaging assessments.在炎症性肠病患者中，vedolizumab 的起始治疗并未引发新发病的脊柱关节炎：一项具有影像学评估的前瞻性 24 周研究。
United European Gastroenterol J. 2024 Sep;12(7):859-869. doi: 10.1002/ueg2.12621. Epub 2024 Jul 4.
3
Diagnosis of Inflammatory Bowel Disease-Associated Peripheral Arthritis: A Systematic Review.炎症性肠病相关外周关节炎的诊断：一项系统评价
Inflamm Bowel Dis. 2025 Mar 3;31(3):812-842. doi: 10.1093/ibd/izae114.
4
Guselkumab provides durable improvement across psoriatic arthritis disease domains: post hoc analysis of a phase 3, randomised, double-blind, placebo-controlled study.古塞单抗可改善银屑病关节炎多领域疾病状况：III 期随机双盲安慰剂对照研究的事后分析。
RMD Open. 2024 Mar 26;10(1):e003977. doi: 10.1136/rmdopen-2023-003977.
5
Peripheral Joint and Enthesis Involvement in Patients With Newly Diagnosed Inflammatory Bowel Disease: Symptoms, and Clinical and Ultrasound Findings - A Population-Based Cohort Study.新诊断炎症性肠病患者的外周关节和附着点受累：症状、临床及超声表现——一项基于人群的队列研究
J Crohns Colitis. 2024 Aug 6;18(7):1053-1070. doi: 10.1093/ecco-jcc/jjae022.
6
ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease.欧洲克罗恩病和结肠炎组织（ECCO）炎症性肠病肠外表现指南
J Crohns Colitis. 2024 Jan 27;18(1):1-37. doi: 10.1093/ecco-jcc/jjad108.
7
Impact of Vedolizumab on Extraintestinal Manifestations in Inflammatory Bowel Disease: Results From a Descriptive, Retrospective, Real-world Study.韦迪珠单抗对炎症性肠病肠外表现的影响：一项描述性、回顾性、真实世界研究的结果。
Inflamm Bowel Dis. 2023 Nov 2;29(11):1713-1722. doi: 10.1093/ibd/izad075.
8
Screening for spondyloarthritis in patients with inflammatory bowel diseases.炎症性肠病患者的脊柱关节炎筛查
Rheumatol Int. 2023 Jan;43(1):109-117. doi: 10.1007/s00296-022-05208-y. Epub 2022 Sep 26.
9
Upadacitinib for the treatment of active non-radiographic axial spondyloarthritis (SELECT-AXIS 2): a randomised, double-blind, placebo-controlled, phase 3 trial.巴瑞替尼治疗活动性非放射性中轴型脊柱关节炎（SELECT-AXIS 2）：一项随机、双盲、安慰剂对照、3 期临床试验。
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10
Joint Disease Activity in Inflammatory Bowel Disease-associated Peripheral Spondyloarthritis Stratifies Therapeutic Response.炎症性肠病相关的外周型脊柱关节炎中的关节疾病活动度可分层治疗反应。
Gastro Hep Adv. 2022;1(2):137-140. doi: 10.1016/j.gastha.2021.12.002. Epub 2022 Feb 7.

合并炎症性脊柱关节炎和炎症性肠病的诊断与管理实用小贴士

Practical Tips for Diagnosis and Management of Concomitant Inflammatory Spondyloarthritis and Inflammatory Bowel Disease.

作者信息

Falloon Katherine, Forney Michael, Cheemalavagu Shashank, Husni M Elaine, Rieder Florian

机构信息

Department of Gastroenterology, Hepatology and Nutrition, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Ave / A30, Cleveland, OH, 44195, USA.

Department of Musculoskeletal Radiology, Cleveland Clinic Foundation, Cleveland, OH, USA.

出版信息

Curr Gastroenterol Rep. 2025 Jul 14;27(1):52. doi: 10.1007/s11894-025-00990-8.

DOI:10.1007/s11894-025-00990-8
PMID:40658153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12259774/
Abstract

PURPOSE OF REVIEW

The goal of this review is to provide practical guidance for gastroenterologists regarding diagnosis and management of inflammatory bowel disease associated spondyloarthritis.

RECENT FINDINGS

While there is limited data regarding optimal management approaches, we summarize available screening tools along with classification and consensus criteria that can be deployed in this setting and offer guidance regarding patient symptoms, physical exam findings, laboratory data, and imaging strategies that may facilitate diagnosis. In addition, we outline various therapeutic options available while highlighting deficits in the currently available literature. Inflammatory bowel disease associated spondyloarthritis is common but remains poorly understood. Ongoing research to establish a clear diagnostic pathway and reproducible treatment targets is essential to better identify and treat this patient population.

摘要

综述目的

本综述的目的是为胃肠病学家提供有关炎症性肠病相关性脊柱关节炎诊断和管理的实用指导。

最新发现

虽然关于最佳管理方法的数据有限，但我们总结了可用的筛查工具以及可在此情况下应用的分类和共识标准，并就可能有助于诊断的患者症状、体格检查结果、实验室数据和影像学策略提供指导。此外，我们概述了各种可用的治疗选择，同时强调了现有文献中的不足。炎症性肠病相关性脊柱关节炎很常见，但仍了解不足。开展研究以建立明确的诊断途径和可重复的治疗靶点对于更好地识别和治疗这一患者群体至关重要。