Benjamin S B, Goodman Z D, Ishak K G, Zimmerman H J, Irey N S
Hepatology. 1985 Nov-Dec;5(6):1163-71. doi: 10.1002/hep.1840050617.
Hepatic histopathology and clinical-pathologic correlations were studied in 77 patients who met clinical criteria for halothane hepatotoxicity. They were divided into groups based on the type of surgery (minor or major) and outcome (nonfatal, biopsy group or fatal, autopsy group). The two nonfatal groups (minor surgery and major surgery) and the two fatal groups (minor surgery and major surgery) were comparable with regard to age, time of onset from exposure, peak aminotransferase values and peak bilirubin determinations. A spectrum of histologic patterns was identified in these patients. It ranged from panlobular and multifocal spotty necrosis resembling viral hepatitis through submassive confluent zonal necrosis to massive necrosis. Progression of severity of injury from spotty to massive necrosis was more closely related to multiple exposures to halothane (and especially repeated exposure within less than three months), than to the extensiveness of the associated surgical procedures.
对77例符合氟烷肝毒性临床标准的患者进行了肝脏组织病理学及临床病理相关性研究。根据手术类型（小手术或大手术）及转归（非致死性，活检组；或致死性，尸检组）将患者分组。两个非致死组（小手术组和大手术组）以及两个致死组（小手术组和大手术组）在年龄、接触后发病时间、转氨酶峰值及胆红素峰值测定方面具有可比性。在这些患者中识别出一系列组织学模式。其范围从类似于病毒性肝炎的全小叶性和多灶性点状坏死，到亚大块融合性带状坏死，再到大块坏死。损伤严重程度从点状坏死进展至大块坏死，与多次接触氟烷（尤其是在不到三个月内反复接触）的关系比与相关外科手术范围的关系更为密切。
