McKinney Reed A, Baumann Kerry B, Foss Robert D
Department of Oral and Maxillofacial Pathololgy, Naval Postgraduate Dental School, Bethesda, MD, USA.
Department of Pathology, Naval Medical Center San Diego, San Diego, CA, USA.
Head Neck Pathol. 2025 Jul 14;19(1):84. doi: 10.1007/s12105-025-01814-x.
BCM is an uncommon cytomorphologic variant with the potential to mimic unrelated neoplastic conditions, especially in the absence of a known cutaneous primary lesion or limited access to immunohistochemical stains.
A 28-year-old male patient presented with recent onset parotid gland mass. The mass was excised, and the subsequent workup elicited an interpretation of metastatic balloon cell melanoma (BCM). Despite an extensive evaluation, no evidence of a primary tumor site was identified.
The diagnosis was confirmed based on positive staining for BRAF, HMB45, Melan-A, PRAME, S100, and SOX-10 in the malignant cells.
Familiarity with the histologic and immunophenotypic findings may help to ensure an accurate diagnosis.
气球状细胞黑色素瘤（BCM）是一种罕见的细胞形态学变异型，有可能模仿不相关的肿瘤性疾病，特别是在没有已知皮肤原发性病变或难以获得免疫组化染色的情况下。
一名28岁男性患者近期出现腮腺肿块。该肿块被切除，随后的检查结果提示为转移性气球状细胞黑色素瘤（BCM）。尽管进行了广泛评估，但未发现原发性肿瘤部位的证据。
根据恶性细胞中BRAF、HMB45、Melan-A、PRAME、S100和SOX-10染色阳性确诊。
熟悉组织学和免疫表型结果可能有助于确保准确诊断。
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