Lee Lili, Zhou Fang, Simms Anthony, Wieczorek Rosemary, Fang Yanan, Subietas-Mayol Antonio, Wang Beverly, Heller Patricia, Huang Hongying, Pei Zhiheng, Osman Iman, Meehan Shane, Lee Peng
Department of Pathology, New York University School of Medicine, New York, NY 10010, USA.
Int J Clin Exp Pathol. 2011 Mar;4(3):315-21. Epub 2011 Mar 22.
A case of metastatic balloon cell malignant melanoma (BCMM) is presented. The balloon melanoma cells (BMC) were absent in the shave biopsy of the primary lesion and present as a minor component in the wide and deep excision. A subsequent right neck lymph node metastasis showed complete replacement of the lymph node by large, foamy cells. Though the tumor was amelanocytic and Fontana-Masson stain failed to reveal melanin, it stained positively for S-100, HMB-45, and Melan-A. Ultrastructurally, the foamy cells were characterized by cytoplasmic vacuolization and a lack of melanosomes. The differential diagnosis of metastatic balloon cell malignant melanoma is broad, and clinicopathologic correlation may play a critical role in achieving the correct diagnosis.
本文报告一例转移性气球状细胞恶性黑色素瘤（BCMM）。原发性病变的削除活检中未发现气球状黑色素瘤细胞（BMC），而在广泛深切除标本中其为次要成分。随后出现的右颈部淋巴结转移表现为淋巴结被大的泡沫细胞完全取代。尽管肿瘤无黑色素生成且Fontana-Masson染色未显示黑色素，但S-100、HMB-45和Melan-A染色呈阳性。超微结构上，泡沫细胞的特征为细胞质空泡化且缺乏黑素小体。转移性气球状细胞恶性黑色素瘤的鉴别诊断范围广泛，临床病理相关性对于做出正确诊断可能起着关键作用。
