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瑞士光源和瑞士自由电子激光装置上大分子晶体学光束线的发展

Evolution of macromolecular crystallography beamlines at the Swiss Light Source and SwissFEL.

作者信息

Wang Meitian

机构信息

Swiss Light Source, Center for Photon Science, Paul Scherrer Institute, Forschungsstrasse 111, 5232 Villigen, Switzerland.

出版信息

J Synchrotron Radiat. 2025 Sep 1;32(Pt 5):1162-1183. doi: 10.1107/S1600577525005016. Epub 2025 Jul 14.

DOI:10.1107/S1600577525005016
PMID:40658592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12416430/
Abstract

This review highlights the development and evolution of three macromolecular crystallography (MX) beamlines at the Swiss Light Source (SLS) over the past two decades. We discuss key advancements in X-ray optics, detectors, goniometers, sample changers and MX methodology, emphasizing their impact on high-throughput and high-resolution structural biology. Our contributions are presented within the broader context of global efforts in synchrotron-based MX. Looking ahead, we explore the future experiments enabled by SLS 2.0 and new opportunities at SwissFEL to enhance experimental capabilities and drive scientific discoveries.

摘要

本综述重点介绍了瑞士光源（SLS）的三条大分子晶体学（MX）光束线在过去二十年中的发展与演变。我们讨论了X射线光学、探测器、测角仪、样品更换器和MX方法学方面的关键进展，强调了它们对高通量和高分辨率结构生物学的影响。我们的贡献是在基于同步加速器的MX全球努力的更广泛背景下呈现的。展望未来，我们探索了SLS 2.0带来的未来实验以及瑞士自由电子激光（SwissFEL）提升实验能力和推动科学发现的新机遇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/798773189559/s-32-01162-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/96eb4eb7d015/s-32-01162-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/3b890f9d66b9/s-32-01162-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/58513ead57bb/s-32-01162-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/982079ef3a95/s-32-01162-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/3135002ba421/s-32-01162-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/385fb69b7dac/s-32-01162-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/310cae5248ae/s-32-01162-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/981bc0a30d0e/s-32-01162-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/798773189559/s-32-01162-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/96eb4eb7d015/s-32-01162-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/3b890f9d66b9/s-32-01162-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/58513ead57bb/s-32-01162-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/982079ef3a95/s-32-01162-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/3135002ba421/s-32-01162-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/385fb69b7dac/s-32-01162-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/310cae5248ae/s-32-01162-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/981bc0a30d0e/s-32-01162-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/364a/12416430/798773189559/s-32-01162-fig9.jpg

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