Gourkhede Rani, Balakrishna Maravanji S
Phosphorus Laboratory, Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Org Lett. 2025 Jul 25;27(29):7874-7878. doi: 10.1021/acs.orglett.5c02186. Epub 2025 Jul 14.
We report a Mn(I) pincer complex, [Mn(CO){-PhPCHC(O)N(CHPPh-)}κ-,,], bearing an amide-functionalized bisphosphine (BalaHariPhos), for the efficient -alkylation of amines with alcohols. The reaction proceeds under base-free conditions at 80 °C, affording -alkylated products in good to excellent yields within 12 h. Broad substrate scope is demonstrated, including the synthesis of indoles and dibenzyl piperazine. Selective mono--methylation of amines using methanol as a C source was also achieved. This work establishes a sustainable, non-noble metal platform for amine functionalization.
