Ataoglu Cagdas, Uyaniker Zeynep Arzum, Erginoglu Ufuk, Ross Miner, Helgager Jeffrey, Baskaya Mustafa K
Departments of Neurological Surgery, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
J Neurosurg Case Lessons. 2025 Jul 14;10(2). doi: 10.3171/CASE25346.
Polymorphous low-grade neuroepithelial tumors of the young (PLNTYs) are rare, generally indolent brain tumors first described in 2017 and recently included as a recognized entity in the 5th edition of the World Health Organization Classification of Tumors of the Central Nervous System. PLNTYs occur most commonly in children and young adults and are often associated with epilepsy and favorable clinical outcomes.
The authors present a case of PLNTY in the third ventricle, an unusual location for this tumor, with operative, histological, and molecular analysis. Notably, they identified a pathogenic TP53 mutation, which has been rarely reported in this tumor type. The operative video demonstrates anatomical and surgical considerations for this rare and newly recognized tumor type.
The authors contribute a new case of PLNTY to the literature, highlighting the uncommon features of this case, including third ventricular localization and the presence of a TP53 mutation. They include a surgical case video for comprehensive visualization. These tumors typically exhibit indolent behavior and can be managed with resection alone. Comprehensive radiological, histological, and molecular evaluation is necessary to distinguish these tumors from other low-grade neoplasms. https://thejns.org/doi/10.3171/CASE25346.
青年多形性低度神经上皮肿瘤（PLNTY）是一种罕见的、通常生长缓慢的脑肿瘤，于2017年首次被描述，最近被纳入世界卫生组织中枢神经系统肿瘤分类第5版中的一个公认实体。PLNTY最常发生于儿童和青年成人，常与癫痫相关，临床预后良好。
作者报告了一例发生于第三脑室的PLNTY病例，该肿瘤位置不常见，并进行了手术、组织学和分子分析。值得注意的是，他们发现了一个致病性TP53突变，该突变在这种肿瘤类型中很少被报道。手术视频展示了针对这种罕见且新认识的肿瘤类型的解剖学和手术注意事项。
作者为文献贡献了一例新的PLNTY病例，突出了该病例的不寻常特征，包括第三脑室定位和TP53突变的存在。他们提供了一个手术病例视频以进行全面展示。这些肿瘤通常表现为生长缓慢的行为，仅通过手术切除即可处理。需要进行全面的放射学、组织学和分子评估，以将这些肿瘤与其他低度肿瘤区分开来。https://thejns.org/doi/10.3171/CASE25346。
