Li Zhongjie, Xu Hao, Cai Xuecheng, Wang Yu, He Lin, Yu Genxi, Dong Anping
Laboratory for Liquid-Solid Structural Evolution & Processing of Materials (Ministry of Education), School of Materials Science & Engineering, Shandong University, Jinan, 250061, PR China; Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China.
Shanghai Key Lab of Advanced High-temperature Materials and Precision Forming, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, PR China; HuBei Engineering Institute, Huangshi, 435003, PR China.
Acta Biomater. 2025 Sep 1;203:1-20. doi: 10.1016/j.actbio.2025.07.032. Epub 2025 Jul 12.
Given the low elastic modulus, favorable bioactivity, and intrinsic biodegradability of Mg alloys, Ti-Mg composites comprising Mg embedded within a continuous Ti matrix are considered a promising alternative to conventional porous Ti alloys. During implantation, the Mg phase undergoes programmable degradation-mediated pore-formation, which synergistically promotes osseointegration and bone infiltration, while the retained Ti matrix provides mechanical support similar to that of porous Ti alloy implants. This review provides a comprehensive analysis of recent advancements in Ti-Mg composites, emphasizing their advantages as implant materials in terms of tunable microstructural architectures and performance optimization potential. First, advanced fabrication techniques, including powder metallurgy (PM), melt infiltration, and liquid metal dealloying (LMD), compatible with Ti-Mg composites are categorized and analyzed. Second, the macrostructure design principle and microstructural characteristics of Ti-Mg composites are reviewed. Subsequently, the corresponding properties of Ti-Mg composites-specifically, mechanical properties, degradation behavior, and both in vitro and in vivo biological evaluations-are systematically discussed. Finally, the challenges and future prospects of Ti-Mg composites are addressed. STATEMENT OF SIGNIFICANCE: Ti-Mg composites with partial degradation characteristics have emerged as a frontier research domain for next-generation bioactive metallic implants. The rapid evolution of advanced manufacturing technologies, particularly high-pressure solid-state sintering, additive manufacturing and liquid metal dealloying, has enabled unprecedented opportunities for biomimetic structural engineering, microstructure optimization, and performance enhancement in these hybrid systems. This review provides a comprehensive analysis of the processing-structure-property relationship in Ti-Mg composites, while critically evaluating current limitations and outlining potential development strategies. The aim of this work is to offer essential insights into bioactive metallic implants with region-specific degradation profiles, thereby facilitating their clinical translation through material innovation.
鉴于镁合金具有低弹性模量、良好的生物活性和固有的生物降解性，由嵌入连续钛基体中的镁组成的钛-镁复合材料被认为是传统多孔钛合金的一种有前途的替代品。在植入过程中，镁相经历可编程的降解介导的孔隙形成，这协同促进骨整合和骨浸润，而保留的钛基体提供与多孔钛合金植入物类似的机械支撑。本文综述对钛-镁复合材料的最新进展进行了全面分析，强调了它们作为植入材料在可调微结构架构和性能优化潜力方面的优势。首先，对与钛-镁复合材料兼容的先进制造技术进行了分类和分析，包括粉末冶金（PM）、熔体浸渗和液态金属脱合金（LMD）。其次，回顾了钛-镁复合材料的宏观结构设计原则和微观结构特征。随后，系统地讨论了钛-镁复合材料的相应性能，特别是机械性能、降解行为以及体外和体内生物学评价。最后，阐述了钛-镁复合材料面临的挑战和未来前景。重要性声明：具有部分降解特性的钛-镁复合材料已成为下一代生物活性金属植入物的前沿研究领域。先进制造技术的快速发展,特别是高压固态烧结、增材制造和液态金属脱合金，为这些混合系统中的仿生结构工程、微观结构优化和性能提升提供了前所未有的机会。本文综述对钛-镁复合材料的加工-结构-性能关系进行了全面分析，同时批判性地评估了当前的局限性并概述了潜在的发展策略。这项工作的目的是为具有区域特异性降解特征的生物活性金属植入物提供重要见解，从而通过材料创新促进其临床转化。
