磷脂酰肌醇翻转决定新霉素敏感性。 - Suppr

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超能文献

Phosphoinositide flipping governs neomycin sensitivity.

作者信息

Salsaa Michael, Fairn Gregory D

机构信息

Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada.

Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada.

出版信息

Nat Cell Biol. 2025 Jul;27(7):1057-1058. doi: 10.1038/s41556-025-01707-9.

DOI:10.1038/s41556-025-01707-9

PMID:40659871

Abstract

摘要

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Phosphoinositide flipping governs neomycin sensitivity.磷脂酰肌醇翻转决定新霉素敏感性。

Nat Cell Biol. 2025 Jul;27(7):1057-1058. doi: 10.1038/s41556-025-01707-9.

Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction.通过新霉素提取鉴定与核磷脂酰肌醇 4,5-二磷酸相互作用的蛋白质。

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Phosphoinositide breakdown is associated with Fc-gamma RII-mediated activation of 5'-lipoxygenase in murine eosinophils.磷酸肌醇分解与Fc-γRII介导的小鼠嗜酸性粒细胞中5'-脂氧合酶的激活有关。

J Immunol. 1991 Mar 1;146(5):1566-70.

Impairment of membrane phosphoinositide metabolism by aminoglycoside antibiotics: streptomycin, amikacin, kanamycin, dibekacin, gentamicin and neomycin.氨基糖苷类抗生素对膜磷酸肌醇代谢的损害：链霉素、阿米卡星、卡那霉素、地贝卡星、庆大霉素和新霉素。

J Pharmacol Exp Ther. 1983 Nov;227(2):415-20.

Phosphoinositide hydrolysis by phospholipase C modulated by multivalent cations La(3+), Al(3+), neomycin, polyamines, and melittin.由多价阳离子镧（3+）、铝（3+）、新霉素、多胺和蜂毒素调节的磷脂酶C介导的磷酸肌醇水解作用

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Neomycin and spermine have similar effects on secretion and phosphoinositide metabolism in ATP-depleted permeabilized adrenal chromaffin cells.新霉素和精胺对ATP耗竭的透化肾上腺嗜铬细胞的分泌和磷酸肌醇代谢具有相似的作用。

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P4-ATPase control over phosphoinositide membrane asymmetry and neomycin resistance.P4-ATP酶对磷酸肌醇膜不对称性和新霉素抗性的控制。

bioRxiv. 2025 Mar 3:2025.03.03.641220. doi: 10.1101/2025.03.03.641220.

Separation of liposome populations differing in phosphoinositide content by chromatography on immobilized neomycin.通过固定化新霉素色谱法分离磷脂酰肌醇含量不同的脂质体群体。

J Pharm Sci. 1989 Feb;78(2):172-5. doi: 10.1002/jps.2600780220.

Contribution of phosphoinositide-dependent signalling to photomotility of Blepharisma ciliate.磷酸肌醇依赖性信号传导对纤毛虫Blepharisma光运动的作用

J Photochem Photobiol B. 2000 Apr-May;55(2-3):120-7. doi: 10.1016/s1011-1344(00)00031-2.

本文引用的文献

P4-ATPases control phosphoinositide membrane asymmetry and neomycin resistance.P4-ATP酶控制磷酸肌醇膜不对称性和新霉素抗性。

Nat Cell Biol. 2025 Jul 11. doi: 10.1038/s41556-025-01692-z.

Modulation of bone marrow haematopoietic stem cell activity as a therapeutic strategy after myocardial infarction: a preclinical study.调节骨髓造血干细胞活性作为心肌梗死后的一种治疗策略：一项临床前研究。

Nat Cell Biol. 2025 Apr;27(4):591-604. doi: 10.1038/s41556-025-01639-4. Epub 2025 Apr 2.

Regulation of phospholipid distribution in the lipid bilayer by flippases and scramblases.翻转酶和 scramblases 对脂质双层中磷脂分布的调节。

Nat Rev Mol Cell Biol. 2023 Aug;24(8):576-596. doi: 10.1038/s41580-023-00604-z. Epub 2023 Apr 27.

Ist2 recruits the lipid transporters Osh6/7 to ER-PM contacts to maintain phospholipid metabolism.Ist2 通过招募脂质转运蛋白 Osh6/7 到内质网-质膜接触位点来维持磷脂代谢。

J Cell Biol. 2021 Sep 6;220(9). doi: 10.1083/jcb.201910161. Epub 2021 Jul 14.

Phosphatidylinositol 4,5-bisphosphate is localized in the plasma membrane outer leaflet and regulates cell adhesion and motility.磷脂酰肌醇 4,5-二磷酸位于质膜的外叶，调节细胞黏附和运动。

Biochem Biophys Res Commun. 2020 Jul 5;527(4):1050-1056. doi: 10.1016/j.bbrc.2020.05.040. Epub 2020 May 18.

ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P).ORP2 将胆固醇交换为磷脂酰肌醇 4,5-二磷酸（PI(4,5)P）递送至质膜。

Mol Cell. 2019 Feb 7;73(3):458-473.e7. doi: 10.1016/j.molcel.2018.11.014. Epub 2018 Dec 20.

Transbilayer lipid asymmetry.跨双层脂质不对称性。

Curr Biol. 2018 Apr 23;28(8):R386-R391. doi: 10.1016/j.cub.2018.01.007.

PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.磷脂酰肌醇-4,5-二磷酸（PI(4,5)P2）被ATP结合盒转运体A1（ABCA1）转运至细胞表面，在那里它介导载脂蛋白A1结合和新生高密度脂蛋白组装。

Circ Res. 2016 Sep 16;119(7):827-38. doi: 10.1161/CIRCRESAHA.116.308856. Epub 2016 Aug 11.

Identification of an overexpressed yeast gene which prevents aminoglycoside toxicity.鉴定出一种可预防氨基糖苷类毒性的过表达酵母基因。

Microbiology (Reading). 1996 Dec;142 ( Pt 12):3407-14. doi: 10.1099/13500872-142-12-3407.

Aminoglycoside antibiotics preferentially increase permeability in phosphoinositide-containing membranes: a study with carboxyfluorescein in liposomes.氨基糖苷类抗生素优先增加含磷酸肌醇膜的通透性：脂质体中羧基荧光素的研究。

Biochim Biophys Acta. 1987 Aug 7;902(1):80-6. doi: 10.1016/0005-2736(87)90137-4.

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