Sharma Pushpender, Jain Chirag, Chauhan Shikha Baghel, Singh Indu
Amity Institute of Pharmacy, Amity University, Noida, UP, 201313, India.
Curr Drug Discov Technol. 2025 Jul 11. doi: 10.2174/0115701638375694250703160236.
A game-changing strategy in precision medicine is theranostics, which is the combination of diagnostics and treatments on one platform. Microrobots have drawn a lot of interest as promising agents in theranostic applications because of their small size, agility, and multifunctionality. This anal-ysis highlights the potential of microrobots to transform illness management by examining how they can integrate precise medicine delivery and diagnostic capabilities. Advanced features like imaging for focused diagnostics, payload delivery for precision therapies, and biosensing for real-time disease monitoring can be built into microrobots. These microrobots can navigate intricate biological environ-ments and provide localized intervention at the cellular and subcellular levels. They are propelled by external pressures such as magnetic fields or biological mechanisms. Recent advancements in micro-robots, including biocompatible polymers and stimuli-responsive systems, offer potential for early dis-ease identification and targeted drug release in neurological, cardiovascular, and malignant diseases. Along with solutions, issues like scalability, regulatory approval, and biocompatibility are also cov-ered. With an emphasis on their role in influencing the development of integrated healthcare solutions, this paper offers a thorough summary of technological developments and potential applications of mi-crorobots in theranostics. The study authors examined databases such as PubMed, Scopus, Google Scholar, and Web of Science for peer-reviewed articles published within the last 10 years on theranostic microrobots, diagnostic tools, drug delivery systems, and precision medicine. It comprised empirical research on microrobot design, functioning, therapeutic applications, diagnostic capabilities, treatment results, and safety profiles. This methodical methodology found patterns, gaps, and advances in the discipline.
精准医学中一项具有变革性的策略是治疗诊断学,即在一个平台上结合诊断与治疗。微型机器人因其体积小、灵活性高和多功能性,作为治疗诊断应用中有前景的媒介引起了广泛关注。本分析通过研究微型机器人如何整合精准给药和诊断能力,突出了其在改变疾病管理方面的潜力。微型机器人可具备先进功能,如用于聚焦诊断的成像、用于精准治疗的载荷递送以及用于实时疾病监测的生物传感。这些微型机器人能够在复杂的生物环境中导航,并在细胞和亚细胞水平提供局部干预。它们由磁场或生物机制等外部压力驱动。微型机器人的最新进展,包括生物相容性聚合物和刺激响应系统,为神经、心血管和恶性疾病的早期疾病识别和靶向药物释放提供了潜力。除了解决方案,还涵盖了可扩展性、监管批准和生物相容性等问题。本文重点阐述了微型机器人在治疗诊断学中的作用对综合医疗解决方案发展的影响,全面总结了微型机器人在治疗诊断学中的技术发展和潜在应用。研究作者查阅了PubMed、Scopus、谷歌学术和科学网等数据库,以获取过去10年内发表的关于治疗诊断微型机器人、诊断工具、药物递送系统和精准医学的同行评议文章。研究包括对微型机器人设计、功能、治疗应用、诊断能力、治疗效果和安全性的实证研究。这种系统的方法发现了该领域的模式、差距和进展。