Perić Aleksandar, Vezmar Kovačević Sandra, Barać Aleksandra, Perić Aneta, Vojvodić Danilo
Department of Otorhinolaryngology, Faculty of Medicine of the Military Medical Academy, https://ror.org/04dt6a039University of Defense, Belgrade, Serbia.
Department of Pharmacokinetics and Clinical Pharmacy, https://ror.org/02qsmb048University of Belgrade Faculty of Pharmacy, Belgrade, Serbia.
Expert Rev Mol Med. 2025 Jul 15;27:e25. doi: 10.1017/erm.2025.10013.
In this short narrative review, we would like to discuss the immunomodulatory effects of South African geranium () root extract EPs7630 in treating acute rhinosinusitis. The plant has been used for centuries to treat respiratory tract inflammation, such as sinusitis, pharyngitis and bronchitis. South African geranium is rich in polyphenols, flavonoids, tannins, diterpenes and proanthocyanidins, but the main constituent is a type of coumarin called 'umckalin' (6-hydroxy-5,5-dimethoxy-coumarin). The substance is standardised as an aqueous-ethanolic extract from the root of this plant under the code name EPs7630.
The article presents the results of and studies of administering this herbal drug in acute viral, post-viral and bacterial rhinosinusitis. The focus is on the immunomodulatory effects of EPs7630 during the therapy of this acute inflammation of the nasal mucosa.
According to the results of some studies, EPs7630 stimulates monocyte-dependent activity and inhibits neutrophil-dependent chemokine activity. However, given the small number of studies, the level of evidence is low, implying the need for new research.
Particular attention should be paid to the effect of EPs7630 on bradykinin, the mediator that triggers most inflammatory processes in acute rhinosinusitis.
在这篇简短的叙述性综述中，我们将讨论南非天竺葵（Pelargonium sidoides）根提取物EPs7630在治疗急性鼻窦炎中的免疫调节作用。这种植物几个世纪以来一直被用于治疗呼吸道炎症，如鼻窦炎、咽炎和支气管炎。南非天竺葵富含多酚、黄酮类化合物、单宁、二萜和原花青素，但主要成分是一种名为“umckalin”（6-羟基-5,5-二甲氧基香豆素）的香豆素。该物质被标准化为从这种植物的根中提取的水乙醇提取物，商品名为EPs7630。
本文介绍了在急性病毒性、病毒感染后和细菌性鼻窦炎中使用这种草药的[具体研究1]和[具体研究2]的结果。重点是EPs7630在治疗这种鼻黏膜急性炎症期间的免疫调节作用。
根据一些研究的结果，EPs7630刺激单核细胞依赖性活性并抑制中性粒细胞依赖性趋化因子活性。然而，鉴于研究数量较少，证据水平较低，这意味着需要进行新的研究。
应特别关注EPs7630对缓激肽的影响，缓激肽是引发急性鼻窦炎中大多数炎症过程的介质。
