Ozer Ozturk Ebru, Aslan Mehmet, Bayındır Tuba
Department of Otorhinolaryngology, Malatya Training and Research Hospital, Malatya, Turkey.
Department of Otorhinolaryngology, Turgut Ozal Medical Center, Inonu University, Malatya, Turkey.
Acta Otolaryngol. 2022 Mar-Apr;142(3-4):329-332. doi: 10.1080/00016489.2022.2048072. Epub 2022 Mar 16.
The impacts of coronavirus disease-2019 (COVID-19) on nasal mucociliary clearance (MCC) have shown conflicting results.
The aim of this study was to determine whether COVID-19 infections affect nasal mucociliary activity using the saccharin test to measure nasal MCC time.
This prospective comparative investigation included 25 patients with COVID-19 infection and 25 healthy controls. The nasal MCC time was assessed using the saccharin test. Saccharin test was applied to COVID-19 patients between the 10th and 20th days of COVID-19 test positivity. Patients admitted to the otolaryngology outpatient clinic with non-nasal symptoms and no history of COVID-19 infection served as the control subjects.
Age, gender distribution, smoking, and alcohol usage, and the existence of other systemic disorders had no statistically significant differences between the groups ( = 0.25, = 0.77, = 1.00, = 0.28, = 0.54, respectively). The COVID-19 group had a mean nasal MCC time of 12.00 ± 2.51 min, compared to 9.77 ± 2.51 min in the control group. The nasal MCC time in the COVID-19 group was statistically significantly longer ( = 0.043).
The COVID-19 infection negatively affects mucociliary activity and causes prolongation of MCC. As the nasal defense mechanism weakens in the early period after COVID-19 infection, susceptibility to respiratory infections may occur.
2019冠状病毒病（COVID-19）对鼻黏液纤毛清除功能（MCC）的影响结果相互矛盾。
本研究旨在通过糖精试验测量鼻腔MCC时间，以确定COVID-19感染是否会影响鼻黏液纤毛活性。
这项前瞻性对比研究纳入了25例COVID-19感染患者和25名健康对照者。采用糖精试验评估鼻腔MCC时间。在COVID-19检测呈阳性后的第10至20天对COVID-19患者进行糖精试验。因非鼻部症状就诊于耳鼻喉科门诊且无COVID-19感染史的患者作为对照对象。
两组在年龄、性别分布、吸烟、饮酒情况以及其他全身性疾病的存在方面，差异均无统计学意义（分别为P = 0.25、P = 0.77、P = 1.00、P = 0.28、P = 0.54）。COVID-19组的平均鼻腔MCC时间为12.00 ± 2.51分钟，而对照组为9.77 ± 2.51分钟。COVID-19组的鼻腔MCC时间在统计学上显著更长（P = 0.043）。
COVID-19感染对黏液纤毛活性有负面影响，并导致MCC延长。由于COVID-19感染后早期鼻防御机制减弱，可能会出现呼吸道感染易感性增加的情况。
