Sneha Sri R, Pavithra T, Vinciya T, Santhosh Kumar V, Harikrishnan N, Begum Rukaiah Fatma, Ankul Singh S
Department of Pharmacology, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.
Department of Pharmaceutical Analysis, Dr. M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.
Front Pharmacol. 2025 Jun 30;16:1561702. doi: 10.3389/fphar.2025.1561702. eCollection 2025.
This review explores the potential of Traditional, Complementary, and Integrative Medicine (TCIM) as an adjunct to conventional therapies for Alzheimer's Disease (AD). Unlike pharmaceutical treatments that primarily offer symptomatic relief, TCIM encompasses holistic approaches that target multiple pathophysiological pathways involved in AD, including tau pathology, oxidative stress, mitochondrial dysfunction, and neuroinflammation. Herbal therapies such as , , and have shown promising neuroprotective effects in preclinical and limited clinical studies. Mind-body practices like Kirtan Kriya meditation have also demonstrated stress-reduction benefits, addressing modifiable risk factors for AD. While current evidence highlights the potential of TCIM interventions to complement standard care, rigorous validation through high-quality randomized controlled trials remains essential. This review underscores the need for integrative, personalized approaches that synergize traditional and modern medical systems to enhance therapeutic outcomes in AD.
本综述探讨了传统、补充和整合医学（TCIM）作为阿尔茨海默病（AD）传统疗法辅助手段的潜力。与主要提供症状缓解的药物治疗不同，TCIM包含针对AD所涉及的多种病理生理途径的整体方法，包括tau病理、氧化应激、线粒体功能障碍和神经炎症。诸如[此处草药名称缺失]、[此处草药名称缺失]和[此处草药名称缺失]等草药疗法在临床前和有限的临床研究中已显示出有前景的神经保护作用。像克坦克里亚冥想这样的身心练习也已证明具有减轻压力的益处，可解决AD的可改变风险因素。虽然目前的证据突出了TCIM干预补充标准护理的潜力，但通过高质量随机对照试验进行严格验证仍然至关重要。本综述强调了整合、个性化方法的必要性，这些方法将传统和现代医疗系统协同起来，以提高AD的治疗效果。
