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用于扩展视野的非惯性扫描角度倍增器。

Non-inertial scan angle multiplier for expanded fields-of-view.

作者信息

Yu Che-Hang, Yu Yiyi, Canzano Joseph S, Fei Yuandong, Smith Spencer LaVere

机构信息

Department of Electrical and Computer Engineering, University of California Santa Barbara, 2002, BioEngineering Building, Santa Barbara, CA 93106-5100, USA.

出版信息

bioRxiv. 2025 Jun 15:2025.06.13.659647. doi: 10.1101/2025.06.13.659647.

DOI:10.1101/2025.06.13.659647
PMID:40661571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12259198/
Abstract

In many laser scan engines, mechanical inertia imposes a tradeoff between mirror diameter (mass) and scan speed (cycle time) and/or scan angle amplitude. Ultimately, this limits the field-of-view and/or scan speed in multiphoton and confocal imaging, laser-based manufacturing, and other applications. To push parameters past this inertia limit, we present a non-inertial (stationary) add-on unit that doubles the scan angle amplitude while preserving both the beam size and cycle time, thus doubling the étendue (optical invariant) and overall system throughput. We demonstrate its use in two-photon calcium imaging of neural activity in living mice. We also adapt the approach to present a phase doubling unit that doubles the maximum range of phase modulators. Finally, we describe further variants including generalizing the approach to Nx scan angle multiplication (N = 2, 3, 4, ...) with diffraction limited performance across a wide scan angle range and over a broad wavelength bandwidth. These non-inertial scan angle multipliers (called Nisam2x, 3x, ...) can expand the capabilities of a range of technologies including imaging, adaptive optics, sensing, marking, and manufacturing.

摘要

在许多激光扫描引擎中,机械惯性导致在镜径(质量)与扫描速度(周期时间)和/或扫描角度幅度之间进行权衡。最终,这限制了多光子和共聚焦成像、基于激光的制造及其他应用中的视场和/或扫描速度。为了突破这一惯性限制来提升参数,我们提出了一种非惯性(固定)附加单元,它能在保持光束尺寸和周期时间不变的情况下将扫描角度幅度翻倍,从而使光学扩展量(光学不变量)和整个系统的吞吐量翻倍。我们展示了其在活体小鼠神经活动的双光子钙成像中的应用。我们还采用该方法提出了一种相位翻倍单元,可使相位调制器的最大范围翻倍。最后,我们描述了进一步的变体,包括将该方法推广到N倍扫描角度倍增(N = 2、3、4、...),在宽扫描角度范围和宽波长带宽内具有衍射极限性能。这些非惯性扫描角度倍增器(称为Nisam2x、3x、...)可以扩展包括成像、自适应光学、传感、标记和制造在内的一系列技术的能力。

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本文引用的文献

1
Improving the scan throughput of polygon scanners.提高多边形扫描仪的扫描通量。
Biomed Opt Express. 2024 Oct 25;15(11):6549-6560. doi: 10.1364/BOE.538757. eCollection 2024 Nov 1.
2
High-throughput deep tissue two-photon microscopy at kilohertz frame rates.千赫兹帧率的高通量深层组织双光子显微镜技术。
Optica. 2023 Jun 20;10(6):763-769. doi: 10.1364/optica.487272. Epub 2023 Jun 15.
3
The Cousa objective: a long-working distance air objective for multiphoton imaging in vivo.Cousa 物镜:一种长工作距离的空气物镜,用于活体多光子成像。
Nat Methods. 2024 Jan;21(1):132-141. doi: 10.1038/s41592-023-02098-1. Epub 2023 Dec 21.
4
Optical coherence tomography-based design for a real-time motion corrected scanning microscope.基于光相干断层扫描的实时运动校正扫描显微镜设计。
Opt Lett. 2023 Jul 15;48(14):3805-3808. doi: 10.1364/OL.490087.
5
Scan multiplier unit for ultrafast laser scanning beyond the inertia limit.用于超越惯性极限的超快激光扫描的扫描倍增器单元。
Optica. 2021 Nov 20;8(11):1403-1404. doi: 10.1364/optica.445254. Epub 2021 Nov 2.
6
Ten-kilohertz two-photon microscopy imaging of single-cell dendritic activity and hemodynamics .单细胞树突活动和血流动力学的10千赫兹双光子显微镜成像
Neurophotonics. 2023 Apr;10(2):025006. doi: 10.1117/1.NPh.10.2.025006. Epub 2023 May 3.
7
Optical gearbox enabled versatile multiscale high-throughput multiphoton functional imaging.光学齿轮箱实现了多功能多尺度高通量多光子功能成像。
Nat Commun. 2022 Nov 2;13(1):6564. doi: 10.1038/s41467-022-34472-6.
8
Breaking trade-offs: Development of fast, high-resolution, wide-field two-photon microscopes to reveal the computational principles of the brain.突破权衡:开发快速、高分辨率、宽场双光子显微镜,揭示大脑的计算原理。
Neurosci Res. 2022 Jun;179:3-14. doi: 10.1016/j.neures.2022.03.010. Epub 2022 Apr 4.
9
Diesel2p mesoscope with dual independent scan engines for flexible capture of dynamics in distributed neural circuitry.双独立扫描引擎的 Diesel2p 介观显微镜,用于灵活捕获分布式神经回路中的动力学。
Nat Commun. 2021 Nov 17;12(1):6639. doi: 10.1038/s41467-021-26736-4.
10
Fast, cell-resolution, contiguous-wide two-photon imaging to reveal functional network architectures across multi-modal cortical areas.快速、细胞分辨率、连续宽场双光子成像,揭示多模态皮层区域的功能网络结构。
Neuron. 2021 Jun 2;109(11):1810-1824.e9. doi: 10.1016/j.neuron.2021.03.032. Epub 2021 Apr 19.