Yu Che-Hang, Yu Yiyi, Canzano Joseph S, Fei Yuandong, Smith Spencer LaVere
Department of Electrical and Computer Engineering, University of California Santa Barbara, 2002, BioEngineering Building, Santa Barbara, CA 93106-5100, USA.
bioRxiv. 2025 Jun 15:2025.06.13.659647. doi: 10.1101/2025.06.13.659647.
In many laser scan engines, mechanical inertia imposes a tradeoff between mirror diameter (mass) and scan speed (cycle time) and/or scan angle amplitude. Ultimately, this limits the field-of-view and/or scan speed in multiphoton and confocal imaging, laser-based manufacturing, and other applications. To push parameters past this inertia limit, we present a non-inertial (stationary) add-on unit that doubles the scan angle amplitude while preserving both the beam size and cycle time, thus doubling the étendue (optical invariant) and overall system throughput. We demonstrate its use in two-photon calcium imaging of neural activity in living mice. We also adapt the approach to present a phase doubling unit that doubles the maximum range of phase modulators. Finally, we describe further variants including generalizing the approach to Nx scan angle multiplication (N = 2, 3, 4, ...) with diffraction limited performance across a wide scan angle range and over a broad wavelength bandwidth. These non-inertial scan angle multipliers (called Nisam2x, 3x, ...) can expand the capabilities of a range of technologies including imaging, adaptive optics, sensing, marking, and manufacturing.
在许多激光扫描引擎中,机械惯性导致在镜径(质量)与扫描速度(周期时间)和/或扫描角度幅度之间进行权衡。最终,这限制了多光子和共聚焦成像、基于激光的制造及其他应用中的视场和/或扫描速度。为了突破这一惯性限制来提升参数,我们提出了一种非惯性(固定)附加单元,它能在保持光束尺寸和周期时间不变的情况下将扫描角度幅度翻倍,从而使光学扩展量(光学不变量)和整个系统的吞吐量翻倍。我们展示了其在活体小鼠神经活动的双光子钙成像中的应用。我们还采用该方法提出了一种相位翻倍单元,可使相位调制器的最大范围翻倍。最后,我们描述了进一步的变体,包括将该方法推广到N倍扫描角度倍增(N = 2、3、4、...),在宽扫描角度范围和宽波长带宽内具有衍射极限性能。这些非惯性扫描角度倍增器(称为Nisam2x、3x、...)可以扩展包括成像、自适应光学、传感、标记和制造在内的一系列技术的能力。